|Full Name||ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1|
|Product Description||Rabbit polyclonal antibody to V-ATPase B1 (ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1)|
|Background||This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq]|
|Synonyms||ATP6B1 antibody, MGC32642 antibody, RTA1B antibody, VATB antibody, VMA2 antibody, VPP3 antibody, ATP6V1B1 antibody, endomembrane proton pump 58 kDa subunit antibody, vacuolar proton pump subunit B 1 antibody, vacuolar proton pump 3 antibody, "H(+)-transporting two-sector ATPase, 58kD subunit antibody", V-ATPase B1 subunit antibody, "vacuolar proton pump, subunit 3 antibody", H+-ATPase beta 1 subunit antibody, "V-type proton ATPase subunit B, kidney isoform antibody", V-ATPase subunit B 1 antibody, "ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 antibody"|
|Cellular Localization||Endomembrane system; Peripheral membrane protein |
|Target||V-ATPase B1 |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human V-ATPase B1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (96%), Rat (97%), Bovine (98%)|