|Full Name||vav 1 guanine nucleotide exchange factor|
|Product Description||Rabbit Polyclonal antibody to VAV1 (vav 1 guanine nucleotide exchange factor)|
|Background||The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq]|
|Synonyms||VAV antibody, VAV1 antibody, oncogene vav antibody, vav proto-oncogene antibody, vav 1 oncogene antibody, proto-oncogene vav antibody, vav 1 guanine nucleotide exchange factor antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human VAV1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Bovine|
|Predict Reactivity Note||Rat (92%), Pig (96%), Bovine (96%)|