|Full Name||vav 1 guanine nucleotide exchange factor|
|Product Description||Rabbit Polyclonal antibody to VAV1 (phospho Tyr174) (vav 1 guanine nucleotide exchange factor)|
|Background||The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq]|
|Target||VAV1 (phospho Tyr174)|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human VAV1 (phospho Tyr174). The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Pig (100%)|