|Full Name||kinase insert domain receptor (a type III receptor tyrosine kinase)|
|Product Description||Rabbit Polyclonal antibody to VEGFR-2 (kinase insert domain receptor (a type III receptor tyrosine kinase))|
|Background||Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq]|
|Synonyms||FLK1 Antibody, kinase insert domain receptor (a type III receptor tyrosine kinase) Antibody, KDR Antibody, VEGFR2 Antibody, VEGFR Antibody, CD309 Antibody, VEGF Receptor 2|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Target||VEGF Receptor 2|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human VEGFR-2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Rabbit, Sheep, Bovine|
|Predict Reactivity Note||Mouse (84%), Rat (84%), Dog (93%), Rabbit (82%), Sheep (92%), Bovine (92%)|