|Full Name||kinase insert domain receptor (a type III receptor tyrosine kinase)|
|Product Description||Chicken polyclonal antibody to VEGFR-2|
|Background||VEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity.|
|Synonyms||P35968, 3791, KDR, VEGFR2, 191306, VEGF receptor 2, Kinase insert domain receptor Protein-ty, VEGF receptor2, Kinase insert domain receptor Proteinty, VEGFR|
|Cellular Localization||Type I membrane protein|
|Target||VEGF receptor 2|
|Immunogen||Recombinant fragment - amino acids 51-119 of VEGF Receptor 2|
|Species Reactivity||Human, Mouse, Rat, Bovine|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Bovine(81%)|