| Full Name | vascular endothelial growth factor A |
| Product Description | Mouse monoclonal antibody [4G3] to VEGF |
| Background | Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. |
| Synonyms | VEGFA, VPF, MGC70609 |
| Specificity | GTX83425 is specific for amino acids 27-233 of human VEGF |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | 4G3 |
| Target | VEGF |
| Isotype | Ig2b |
| Immunogen | Recombinant protein expressed in E.coli corresponding to amino acids 27-233 of human VEGF |
| Antigen Species | Human |
| Species Reactivity | Human, Dog |