|Full Name||vascular endothelial growth factor A|
|Product Description||Rabbit Polyclonal antibody to VEGF (vascular endothelial growth factor A)|
|Background||This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq]|
|Synonyms||MGC70609 antibody, MVCD1 antibody, VEGF antibody, VPF antibody, VEGFA antibody, vascular permeability factor antibody, vascular endothelial growth factor A antibody|
|Cellular Localization||Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human VEGF. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Dog, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Dog (83%), Rhesus Monkey (86%), Bovine (83%)|