|Full Name||vaccinia related kinase 1|
|Product Description||Rabbit Polyclonal antibody to VRK1 (vaccinia related kinase 1)|
|Background||This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq]|
|Synonyms||MGC117401 antibody, MGC138280 antibody, MGC142070 antibody, PCH1 antibody, VRK1 antibody, vaccinia-related kinase 1 antibody, serine/threonine-protein kinase VRK1 antibody, vaccinia virus B1R-related kinase 1 antibody, vaccinia related kinase 1 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human VRK1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (83%), Rat (81%), Pig (86%), Rhesus Monkey (98%), Bovine (89%)|