|Full Name||Wolf-Hirschhorn syndrome candidate 2|
|Product Description||Rabbit Polyclonal antibody to WHSC2 (Wolf-Hirschhorn syndrome candidate 2)|
|Background||This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. [provided by RefSeq]|
|Synonyms||FLJ10442 antibody, FLJ25112 antibody, NELF-A antibody, NELFA antibody, WHSC2 antibody, negative elongation factor A antibody, wolf-Hirschhorn syndrome candidate 2 protein antibody, Wolf-Hirschhorn syndrome candidate 2 antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human WHSC2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Zebrafish, Xenopus laevis, Chicken, Chimpanzee, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (94%), Rat (94%), Zebrafish (87%), Xenopus laevis (90%), Chicken (89%), Chimpanzee (100%), Bovine (94%)|