|Full Name||wingless-type MMTV integration site family, member 3|
|Product Description||Rabbit Polyclonal antibody to WNT3 (wingless-type MMTV integration site family, member 3)|
|Background||The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq]|
|Synonyms||INT4 antibody, MGC131950 antibody, MGC138321 antibody, MGC138323 antibody, WNT3 antibody, WNT-3 proto-oncogene protein antibody, proto-oncogene Int-4 homolog antibody, proto-oncogene Wnt-3 antibody, wingless-type MMTV integration site family, member 3 antibody|
|Cellular Localization||Secreted , extracellular space , extracellular matrix |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human WNT3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Chicken, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (99%), Zebrafish (91%), Chicken (98%), Bovine (99%)|