|Full Name||wingless-type MMTV integration site family, member 4|
|Product Description||Rabbit Polyclonal antibody to WNT4 (protein Wnt-4)|
|Background||The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq]|
|Synonyms||SERKAL antibody, WNT-4 antibody, WNT4 antibody, protein Wnt-4 antibody, "wingless-type MMTV integration site family, member 4 antibody"|
|Cellular Localization||Secreted , extracellular space , extracellular matrix |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human WNT4. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Japanese medaka, Xenopus laevis, Chicken|
|Predict Reactivity Note||Japanese medaka (85%), Xenopus laevis (90%), Chicken (89%)|