cancer

Oncogenes

The products of metazoan cell proto-oncogenes are generally key constituents of the cell signaling and gene expression machinery that regulate cell growth and proliferation. When mutated, amplified, or otherwise expressed in a dysregulated manner, these genes can become cellular oncogenes and their oncoprotein products drive tumorigenic cell growth. Examples of proto-oncogenes include the RAS genes, ERBB2, MYC, and ABL1. Certain viruses, or oncoviruses, have the capability to cause cancers through the action of viral genome-encoded oncoproteins that target metazoan cell factors or pathways.

 
Akt Signaling  |  Cell Cycle  |  Cell Death  |  Cancer Metabolism  | Hedgehog Signaling  |  Notch Signaling
Ras Signaling | Receptor tyrosine kinases  |  Fos/Jun Signaling  |  Myc Signaling  |  WNT/β-catenin Signaling
 

Highlighted Products

 
 

CDK4 antibody (GTX102993; green) & p21 antibody (GTX629543; red)_GeneTex


CDK4 antibody (green) & p21 antibody (red)

 
 
 
 
 
 
 
 
 
 
 
 
 
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Akt Signaling 

Protein Product name Clonality Reactivity Application Citation
AKT AKT antibody [N3C2], Internal Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-P, IP, WB
AKT antibody Rb pAb Hu, Ms, Rat, Bov IHC, IP, WB
AKT antibody Chk pAb Hu, Ms, Cow, Rat, Xl WB
AKT (phospho Ser473/474/472) antibody Rb pAb Hu IP, WB
Bax Bax antibody [N1N2], N-term Rb pAb Hu, Rat ICC/IF, IHC-P, IP, WB
Bax antibody [E63] Rb pAb Hu, Ms, Rat ELISA, IHC-P, IP, WB  
Bax antibody [2D3] Ms mAb Hu, Cow, Dog, Rat, Cat WB  
Bax antibody [5B7] Ms mAb Ms ICC/IF, WB
FKHR/ FOXO FOXO1 antibody Rb pAb Ms IHC-P  
FOXO1 (phospho Ser319) antibody Rb pAb Hu, Ms, Mk, Pig, Rat, Bov ICC/IF, IHC-P, IP, WB  
FOXO3A antibody [C3], C-term Rb pAb Hu, Ms ICC/IF, IHC-P, IP, WB
FOXO4 antibody Rb pAb Hu ICC/IF, IHC-P, WB  
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Cell Cycle

Protein Product name Clonality Reactivity Application Citation
ABL ABL1 antibody Rb pAb Hu, Ms, Rat IHC-P, WB  
c-Abl antibody Rb pAb Hu ICC/IF, IHC-P, WB  
Cdk2 CDK2 antibody Rb pAb Hu, Ms, Rat WB  
CDK2 antibody [1A6] Ms mAb Hu, Ms ELISA, FACS, ICC/IF, IHC, IHC-P, WB  
CDK2 antibody [2B6] Ms mAb Hu, Ms, Rat IHC-Fr, IHC-P, WB
CDK2 (phospho Thr160) antibody Rb pAb Hu, Ms, Chk, Pig, Rat, Zfsh, Rb, Shp, Bov IHC, IHC-P, WB  
Cdk4 CDK4 antibody Rb pAb Hu, Ms ICC/IF, IHC-P, WB
CDK4 antibody Rb pAb Hu ICC/IF, WB  
CDK4 antibody [GT624] Ms mAb Hu WB  
CDK4 antibody [DCS-31] Ms mAb Hu, Ms, Rat ICC/IF, IP, WB  
Cyclin D Cyclin D1 antibody [N1C3] Rb pAb Hu, Ms, Rat IHC-P, IP, WB
Cyclin D1 antibody [N2C3] Rb pAb Hu, Ms ICC/IF, IHC-P, WB
Cyclin D1 antibody [SP4] Rb pAb Hu, Ms, Rat IHC, IHC-P, WB
Cyclin D1 (phospho Thr286) antibody Rb pAb Hu, Rat IHC, IHC-P, WB  
Cyclin D3 antibody Rb pAb Hu, Ms ICC/IF, IHC-P, WB
Cyclin E Cyclin E antibody Rb pAb Hu, Ms, Rat IHC-Fr, IP, WB
Cyclin E antibody (ready-to-use) Rb pAb Hu, Ms IHC-P  
Cyclin E1 antibody Rb pAb Hu ICC/IF, WB  
Cyclin E1 (phospho Thr395) antibody Rb pAb Hu IHC, IHC-P, WB  
Cyclin E2 antibody Rb pAb Hu, Ms ELISA, IP, WB  
Cyclin E2 antibody Chk pAb Hu, Ms, Rat WB  
Aurora A Aurora A antibody [C3], C-term Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB  
Aurora A antibody [35C1] Ms mAb Hu, Ms ICC/IF, IHC, IP, WB
Aurora A (phospho Thr288) antibody Rb pAb Hu, Ms IHC-P  

MDM2

MDM2 antibody [N1N3] Rb pAb Hu, Ms, Rat IP, WB, ChIP assay  
MDM2 antibody Rb pAb Hu, Ms ICC/IF, IHC-P, IP, WB, ChIP assay  
MDM2 antibody Rb pAb Hu ICC/IF, IHC-P
MDM2 antibody [SMP14] Ms mAb Hu, Ms IHC-Fr, IHC-P, IP, IHC-R  
HPV-E6
(viral protein)
Human Papilloma virus type 16/18 E6 antibody [C1P5] Ms mAb Virus IHC-P, IP, WB
Human Papilloma virus type 18 E6 antibody [BF7] Ms mAb Virus ELISA, IHC, RIA, WB  
HPV-E7
(viral protein)
Human Papilloma virus type 18 E7 antibody [718-15] Ms mAb Virus ELISA, WB
Human Papilloma virus type 16 E7 antibody [TVG-701Y] Ms mAb Virus ELISA, FACS, IHC-Fr, IP, WB  
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Cell Death

Protein Product name Clonality Reactivity Application Citation
Fas Fas antibody Rb pAb Hu, Ms, Dog, Rat FACS, IHC, WB
Fas antibody [ZB4] Ms mAb Hu Blocking, FACS, IHC, WB
Fas antibody [4F8H6] Ms mAb Hu ELISA, FACS, ICC/IF, WB  
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Cancer Metabolism

Protein Product name Clonality Reactivity Application Citation
PDK1 PDK1 antibody Rb pAb Hu, Ms ICC/IF, IP, WB
PDK1 (phospho Ser241) antibody Rb pAb Hu, Ms, Rat IHC-P, WB  
PKM PKM antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB
PKM2 [AT4M3] antibody Ms mAb Hu, Ms ELISA, ICC/IF, WB
LDHA LDHA antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB  
LDHA antibody [2B11] Ms mAb Hu IHC, IHC-P, IP, WB  
GAC Glutaminase C antibody Rb pAb Hu, Ms ICC/IF, IHC-P, IP, WB  
Glutaminase C antibody Rb pAb Hu ICC/IF, IHC-P, IP, WB  
Glutaminase C antibody [GT1075] Ms mAb Hu ICC/IF, WB  
Glutaminase C antibody [GT3211] Ms mAb Hu ICC/IF, WB  
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Hedgehog Signaling

Protein Product name Clonality Reactivity Application Citation
Gli GLI1 antibody Rb pAb Hu ICC/IF, IP, WB  
GLI1 antibody Rb pAb Hu WB  
GLI1 antibody Rb pAb Ms WB  
GLI1 antibody Rb pAb Hu, Ms ELISA, ICC/IF, IHC, IHC-P, WB
SMO Smo antibody Rb pAb Zfsh WB  
SMO antibody, Internal Gt pAb Hu WB  
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Notch Signaling

Protein Product name Clonality Reactivity Application Citation
NOTCH1 NOTCH1 antibody Rb pAb Hu, Ms, Rat ELISA, ICC/IF, IHC, IHC-P, Neut, WB
NOTCH1 antibody [4C9] Ms mAb Hu IHC, IHC-P, WB  
NOTCH1 antibody [3E12]GLI1 antibody Ms mAb Hu ICC/IF, IHC, IHC-P, WB  
NOTCH2 NOTCH2 antibody [C2], C-term Rb pAb Hu, Ms WB, ChIP-seq  
Notch 2 antibody [HMN2-35] Hamster mAb Ms, Rat FACS  
NOTCH3 Notch 3 antibody [C3], C-term Rb pAb Hu WB  
NOTCH3 antibody, C-term Gt pAb Hu IHC, IHC-P  
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Ras Signaling

Protein Product name Clonality Reactivity Application Citation
Ras Ras antibody Rb pAb Hu, Rat IHC-P, WB  
Ras (G12D Mutant Specific) antibody Rb pAb Hu IHC-P, WB  
Ras (G13D Mutant Specific) antibody Rb pAb Hu IHC-P, WB  
Ras (G13D Mutant Specific) antibody Rb pAb Hu WB  
Ras (Q61R Mutant specific) antibody Rb pAb Hu WB  
Ras (A59T Mutant Specific) antibody Rb pAb Hu WB  
Ras (Q61R Mutant Specific) antibody Rb pAb Hu WB  
Ras (Q61R Mutant Specific) antibody Rb pAb Hu WB  
Ras (K117N Mutant Specific) antibody Rb pAb Hu WB  
H-Ras antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB  
N-Ras antibody Rb pAb Hu ELISA, WB  
B-Raf B-Raf antibody [N2C1], Internal Rb pAb Hu, Ms, Rat IHC-P, IP, WB
B-Raf antibody [1E2] Ms mAb Hu FACS, ICC/IF, IHC, IHC-P, WB  
B-Raf antibody [5A9] Ms mAb Hu, Mk FACS, ICC/IF, IHC, IHC-P, WB  
B-Raf antibody [3A7] Ms mAb Hu, Dog, Mk, Rat ICC/IF, IHC, IHC-P, WB  
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Receptor Tyrosine Kinases

Protein Product name Clonality Reactivity Application Citation
EGF EGFR antibody [N1-2], N-term Rb pAb Hu, Ms FACS, ICC/IF, IHC-P, IP, WB
EGFR antibody [GT133] Ms mAb Hu ICC/IF, IHC-P, IP, WB  
EGFR antibody [GT461] Ms mAb Hu ICC/IF, IP, WB  
Insulin Receptor Insulin Receptor antibody Rb pAb Hu, Ms IHC-P, WB
Insulin Receptor antibody Rb pAb Hu IHC-P  
PDGFR PDGF Receptor alpha antibody [N2C2], Internal Rb pAb Hu, Ms WB
PDGF Receptor beta antibody Rb pAb Hu, Rat ICC/IF, IHC-P, WB  
PDGF Receptor beta antibody [Y92], C-term Rb pAb Hu, Ms, Rat ICC/IF, IHC-Fr, IHC-P, IP, WB  
VEGFR VEGF Receptor 1 antibody Rb pAb Hu WB  
VEGF Receptor 1 antibody [Y103] Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB  
VEGF Receptor 1 (phospho Tyr1213) antibody Rb pAb Hu, Ms, Rat WB  
VEGFR-2 antibody Rb pAb Hu, Ms, Rat IHC, IHC-P, WB
VEGFR-2 antibody Rb pAb Hu, Ms, Rat, Bov IHC, IHC-F, IHC-P, WB
VEGFR-2 (phospho Tyr1175) antibody Chk pAb Hu, Ms, Pig, Rat, Shp ICC/IF, IHC, IHC-P, WB  
VEGFR-2 (phospho Tyr1214) antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-P, WB  
VEGFR-1 + VEGFR-2 antibody Rb pAb Hu, Ms, Rat ICC/IF, WB  
VEGF Receptor 3  antibody Rb pAb Hu WB  
VEGFR-3 antibody (ready-to-use) Rb pAb Hu, Ms, Rat IHC-P  
AXL AXL antibody Rb pAb Hu ELISA, IHC-P, WB  
AXL antibody Rb pAb Hu IHC-P, WB  
AXL antibody [C2C3], C-term Rb pAb Hu IHC-P, WB
DDR DDR1 antibody [N1N3] Rb pAb Hu, Ms IHC, IHC-P, WB
DDR1 antibody [C1C3] Rb pAb Hu IHC-P, WB  
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Fos/Jun Signaling

Protein Product name Clonality Reactivity Application Citation
c-Fos c-Fos antibody Rb pAb Hu WB  
c-Fos antibody Rb pAb Hu WB  
c-Fos antibody Rb pAb Hu, Ms, Rat IHC, IHC-P, IP, WB
c-Jun c-Jun antibody [C1C3] Rb pAb Hu WB
c-Jun antibody [5B1] Ms mAb Hu, Ms, Mk ELISA, FACS, ICC/IF, IHC, IHC-P, WB  
c-Jun antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-P, WB  
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Myc Signaling

Protein Product name Clonality Reactivity Application Citation
c-Myc c-Myc antibody Rb pAb Hu, Ms ICC/IF, IP, WB, ChIP assay
c-Myc antibody [N1], N-term Rb pAb Hu ICC/IF, WB
c-Myc antibody [GT168] Ms mAb Hu FACS, IHC-P, IP, WB
c-Myc antibody [9E10] Ms mAb Hu ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB  
c-Myc antibody [1A6] Ms mAb Hu FACS, ICC/IF, IHC-P, WB  
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WNT/β-catenin Signaling

Protein Product name Clonality Reactivity Application Citation
β-catenin beta Catenin antibody [N1N2-2], N-term Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB, ChIP assay
beta Catenin antibody Rb pAb Hu, Ms ICC/IF, IHC, IHC-P, WB
beta Catenin antibody [GT3171] Ms mAb Hu WB  
WNT Wnt1 antibody Rb pAb Hu WB
Wnt1 antibody [10C8] Ms mAb Hu, Ms ELISA, FACS, ICC/IF, IHC-P, WB  
Wnt7b antibody Rb pAb Hu, Ms IHC-P, WB
Sox2 SOX2 antibody [N1C3] Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC-P, IP, WB
SOX2 antibody [GT1352] Ms mAb Hu, Ms FACS, ICC/IF, IHC-Fr, IHC-P, WB  
SOX2 antibody [GT1876] Ms mAb Hu, Ms, Zfsh FACS, IHC-Fr, IP, WB  
 
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