cancer

Tumor Suppressor Genes

Tumor suppressor gene products act as barriers to block cells from proceeding down the path to cancer. In contrast to the protein products of proto-oncogenes, some tumor suppressor proteins act to restrain abnormal cell proliferation. Others promote cell death pathways or function in DNA repair. While mutated proto-oncogenes behave in a dominant fashion, tumor suppressor genes are generally recessive, thus requiring that both be inactivated or otherwise compromised in order for cancers to occur. Well-described examples of tumor suppressor genes include RB1, TP53, APC and CDKN2A.

 
Akt Signaling  |  Cell Cycle  |  DNA Damage & Repair   | Cancer Metabolism  |  TGF-β Signaling WNT  | β-catenin Signaling
 

Highlighted Products

 
 
 
 
 
 
 
 
 
 
 
 
 
   
 
 
 
 
 
 
 
 
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Akt Signaling

Protein Product name Clonality Reactivity Application Citation
PI3K PI3K p85 beta antibody [N3C3] Rb pAb Hu WB
PI3K p85 beta antibody [N3C3-2] Rb pAb Hu WB  
PI3K p85 beta antibody [T15] Ms mAb Hu, Mk, Bov FACS, IHC-Fr, IP, WB  
PI3K p110 beta antibody [N3C2], Internal Rb pAb Hu, Ms, Rat ICC/IF, WB
PI3K C2 alpha antibody [C3], C-term Rb pAb Hu ICC/IF, IHC-P, WB  
PI3K gamma antibody [C3], C-term Rb pAb Hu, Ms IHC-P, WB  
Bcl2 BCL2 antibody Rb pAb Hu WB  
Bcl-2 antibody [N1N2], N-term Rb pAb Hu, Ms, Rat IHC-P, WB
Bcl-2 antibody [100] Ms mAb Hu FACS, IHC-Fr, IHC-P, IP, WB  
INPP4B INPP4B antibody, Internal Rb pAb Hu ELISA, FACS, IHC, IHC-P, WB  
LKB1 LKB1 antibody Rb pAb Hu, Ms IHC-P, WB  
PTEN PTEN antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB
PTEN (phospho Thr366/Ser370) antibody Rb pAb Hu WB  
TSC TSC1 antibody Rb pAb Hu WB  
TSC1 antibody Rb pAb Hu, Ms, Rat IHC-P, WB  
TSC1 antibody, C-term Gt pAb Hu IHC, IHC-P, WB  
TSC2 antibody Rb pAb Ms ELISA, ICC/IF, WB  
TSC2 (phospho Ser939) antibody Rb pAb Hu, Ms, Mk, Rat IHC, IHC-P, WB  
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Cell Cycle

Protein Product name Clonality Reactivity Application Citation
p15 p15 INK4b antibody [DCS114.1] Ms mAb Hu IHC, IHC-Fr, IP, WB
CDKN2A p14ARF antibody Rb pAb Hu ICC/IF, IP, WB  
p14ARF antibody Rb pAb Hu IP, WB  
p14ARF antibody Rb pAb Hu ICC/IF, IHC, IHC-Fr, IHC-P, WB
p14ARF antibody (ready-to-use) Rb pAb Hu IHC, IHC-P
p14ARF antibody [1D7D2] Ms mAb Hu ELISA, FACS, IHC-P, WB  
p19ARF antibody Rb pAb Hu, Ms ELISA, ICC/IF, IHC-P, IP, WB, ChIP assay
CDKN2A / p16INK4a (phospho Ser326) antibody Rb pAb Hu IHC, IHC-P, WB  
p57 p57 Kip2 antibody Rb pAb Hu ELISA, ICC/IF, WB  
p57 Kip2 antibody [57P06] Ms mAb Ms IHC-P, IP  
Rb Rb antibody Rb pAb Hu IP, ICC/IF, IHC-P, WB  
Rb antibody [Rb] Ms mAb Hu, Ms, Rat, Chmp IHC, IHC-Fr, IP, WB
Rb cleaved antibody [172C1094] Ms mAb Hu, Ms IHC, IHC-P, WB
Chk Chk1 antibody [C1C2-6], Internal Rb pAb Hu ICC/IF, IHC-P, WB
Chk1 (phospho Ser345) antibody [C1C2], Internal Rb pAb Hu, Ms ICC/IF, IHC-P, WB  
Chk2 antibody [8F12] Ms mAb Hu ICC/IF, WB
Chk2 antibody [5C4] Ms mAb Hu, Dog FACS, ICC/IF, IHC, IHC-P, WB  
Chk2 antibody [10G7] Ms mAb Hu, Dog, Mk FACS, ICC/IF, IHC, IHC-P, WB  
Chk2 antibody [2H5] Ms mAb Hu, Dog FACS, IHC, IHC-P, WB  
Chk2 (phospho Thr387) antibody Rb pAb Hu, Ms, Pig, Rat, Bov IHC, IHC-P, WB  
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DNA Damage & Repair

Protein Product name Clonality Reactivity Application Citation
p53 p53 antibody Rb pAb Hu ICC/IF, IHC-P, IP, WB, ChIP assay
p53 antibody [D01] Ms mAb Hu ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB
p53 antibody [Pab240] Ms mAb Hu, Ms, Dog ELISA, FACS, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
p53 antibody [Pab1801] Ms mAb Hu ELISA, FACS, IHC-Fr, IHC-P, IP, RIA, WB, ChIP assay
ATM ATM antibody [2C1] Ms mAb Hu, Ms, Mk, Rat ELISA, FACS, ICC/IF, IHC-P, IP, WB, IHC-R, ChIP assay
ATM antibody [5C2] Ms mAb Hu, Ms, Mk, Rat ICC/IF, IHC, IP, WB
ATM (phospho Ser1981) antibody Rb pAb Hu WB
ATR ATR antibody [N1N2-2], N-term Rb pAb Hu ICC/IF, WB
ATR antibody [2B5] Ms mAb Hu ICC/IF, IP, WB, Functional Assay
ATR (phospho Thr1989) antibody Rb pAb Hu ICC/IF, IHC-P, IP, WB
ATR (phospho Thr1989) antibody [GT222] Ms mAb Hu IP  
BRCA BRCA1 antibody [17F8] - ChIP grade Ms mAb Hu, Ms ELISA, ICC/IF, IHC, IHC-P, IP, WB, ChIP assay
BRCA1 antibody [8F7] Ms mAb Hu, Ms IHC, IHC-P, IP, WB
BRCA1 antibody [6B4] - ChIP grade Ms mAb Hu, Ms ICC/IF, IHC, IP, WB, ChIP assay
BRCA2 antibody [3E6] Ms mAb Hu ICC/IF, IHC, IP, WB
BRCA2 antibody [5F6] Ms mAb Hu IHC, IHC-Fr, IHC-P, WB
BRCA2 antibody [9D3] Ms mAb Hu IHC, IHC-P, IP, WB
RAD51 Rad51 antibody [14B4] Ms mAb Hu, Ms, Chk ICC/IF, IHC-P, IP, WB
Rad51 antibody [N1C2] Rb pAb Hu, Ms ICC/IF, IHC-P, IP, WB
Rad51 antibody Rb pAb Hu ICC/IF, IHC-P, IP, WB
Ku70 Ku70 antibody [N1N3] Rb pAb Hu ICC/IF, IHC-P, WB
Ku70 antibody Rb pAb Hu ICC/IF, IHC-P, IP, WB  
Ku70 antibody Ms mAb Hu WB
Ku80 Ku80 antibody [N3C2], Internal Rb pAb Hu ICC/IF, IHC-P, IP, WB
Ku80 antibody [149.8] Ms mAb Hu ICC/IF, WB
Ku80 antibody [9403] Ms mAb Hu ICC/IF, WB  
FANCs FANCA antibody [N1], N-term Rb pAb Hu ICC/IF, IHC-P, WB
FANCC antibody [N1C1] Rb pAb Hu, Ms ICC/IF, IHC-P, WB
FANCD2 antibody Rb pAb Hu, Ms ICC/IF, IHC, IP, WB
FANCD2 antibody [N1], N-term Rb pAb Hu IHC-P, WB
FANCD2 antibody [103] Ms mAb Hu ELISA, WB  
FANCE antibody [N3C3] Rb pAb Hu IHC-P, WB  
NBS1 NBS1 antibody Rb pAb Hu ICC/IF, IP, WB
NBS1 antibody Rb pAb Hu ICC/IF, IP, WB
NBS1 antibody [1D7] Ms mAb Hu, Ms, Rat ICC/IF, IP, WB
NBS1 antibody [1C3] Ms mAb Hu, Ms ICC/IF, IP, WB
NBS1 (phospho Ser343) antibody Rb pAb Hu, Ms, Rat WB
WT1 Wilms Tumor 1 antibody Rb pAb Ms, Rat IHC-P  
Wilms Tumor 1 antibody Rb pAb Hu, Ms, Rat EMSA, IHC, IHC-P, IP, WB
MUTYH MUTYH antibody [N3C3] Rb pAb Hu, Ms WB  
BLM BLM antibody [C3], C-term Rb pAb Hu, Ms ICC/IF, IHC-P, WB  
BLM antibody [N1N2], N-term Rb pAb Hu ICC/IF, WB  
WRN WRN antibody Rb pAb Hu ICC/IF, IHC-P, WB
WRN antibody [C3], C-term Rb pAb Hu ICC/IF, WB  
XPA/B/C XPA antibody [N2C3] Rb pAb Hu, Ms ICC/IF, IHC-P, WB  
XPA antibody Rb pAb Hu ICC/IF, WB  
XPB antibody Rb pAb Hu, Ms ICC/IF, WB  
XPC antibody Rb pAb Hu ICC/IF, IP, WB
XPC antibody [C2C3], C-term Rb pAb Hu ICC/IF, IHC-P, WB  
XPC antibody [3.26] Ms mAb Hu, Ms ICC/IF, IHC-P, WB
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Cancer Metabolism

Protein Product name Clonality Reactivity Application Citation
VHL Von Hippel Lindau antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB
Von Hippel Lindau antibody [SPM324] (ready-to-use) Ms mAb Hu, Ms IHC-P  
FH CDK2 antibody [2B6] Ms mAb Hu, Ms, Rat IHC-P, IHC-Fr, WB  
Fumarate hydratase antibody [1F10] Ms mAb Hu, Dog, Rat FACS, ICC/IF, IHC, IHC-P, WB  
Fumarate hydratase antibody [9G4] Ms mAb Hu, Dog, Rat FACS, ICC/IF, IHC, IHC-P, WB  
SDH SDHA antibody [C1C3] Rb pAb Hu, Ms IHC-P, WB
SDHA antibody Rb pAb Hu, Ms ICC/IF, IHC-P, WB  
SDHA antibody [GT20710] Ms mAb Hu WB  
SDHB antibody [C2C3], C-term Rb pAb Hu, Ms ICC/IF, IHC-P, WB
SDHB antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB  
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WNT-β catenin Signaling

Protein Product name Clonality Reactivity Application Citation
 BMPR BMPR1A antibody [4B7B2] Ms mAb Hu, Ms ELISA, FACS, ICC/IF, IHC, IHC-P, WB  
BMPR1B antibody [N3C3] Rb pAb Hu, Ms, Cow IHC-P, WB
SMAD SMAD2 antibody Rb pAb Hu ICC/IF, IP, WB, ChIP assay
SMAD3 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB, ChIP assay  
SMAD4 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB  
TGFbR TGF beta Receptor 1 antibody Rb pAb Hu, Ms, Pig, Rat FACS, ICC/IF, IHC-P, WB
TGF beta receptor 1 antibody [3A11] Rb mAb Ms IHC, WB  
TGF-beta Receptor 2 antibody Rb pAb Hu, Ms, Rat WB  
TGF beta receptor 2 antibody [6G11] Rb mAb Ms WB  
TGF beta Receptor 3 antibody Rb pAb Hu WB  
TGF beta receptor 3 antibody [5G9] Rb mAb Hu IHC-P, WB  
MEN1 Menin antibody [N1C1] Rb pAb Hu IP, WB  
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β-catenin Signaling

Protein Product name Clonality Reactivity Application Citation
APC APC antibody [C3], C-term Rb pAb Hu, Ms ICC/IF, IHC, IHC-P
APC antibody Rb pAb Hu, Ms IHC, IHC-P
APC antibody [CC-1] Ms mAb Hu, Ms, Rat ICC/IF, IHC-F, IHC-Fr, IHC-P, WB
AXIN AXIN1 antibody [N1N2], N-term Rb pAb Hu, Ms, Rat WB  
Axin 2 antibody Rb pAb Ms, Rat ELISA, ICC/IF, IHC, IHC-P, WB  
a-Catenin alpha Catenin antibody [N1N3] Rb pAb Hu, Ms ICC/IF, IHC-P, IP, WB  
alpha Catenin antibody [1G5] Ms mAb Hu ICC/IF, IP, WB  
E-cadherin E-Cadherin antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB
E-Cadherin antibody [N3C2], Internal Rb pAb Hu, Rat ICC/IF, IP, WB
E-Cadherin antibody [GT477] Ms mAb Hu IP, WB  
E-Cadherin (phospho Ser838/840) antibody Rb pAb Hu, Rat IP, WB  
Parafibromin Parafibromin antibody [N1C1] Rb pAb Hu WB  
 
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