Amyotrophic lateral sclerosis
5 Sep 2017

Amyotrophic lateral sclerosis (ALS) is an invariably fatal adult-onset neurodegenerative disorder characterized by the progressive loss of both upper and lower motor neurons. The major clinical presentation of ALS is muscle weakness and atrophy affecting speech, swallowing, and movement, with respiratory failure being the most common reason for death usually within 3-5 years of diagnosis. Though the cause is unknown, recent studies have identified several genes associated with the disease including SOD1, TARDBP, FUS, C9orf72, C21orf2, and most recently NEK1.


GeneTex is proud to offer exceptional antibodies against these targets relevant to ALS. Please see the examples highlighted below and the accompanying table to find the reagent that facilitates your ALS research.


 


Representative Product Citations:
 


alpha Tubulin 4a antibody (GTX112141)
J Pathol.
2017 Jun; 242(2):134-139.
Sci Rep.
2017 Jun 19;7(1):3842.
  alpha Tubulin 4a antibody (GTX113098)
Oncogene.
2011 May 26;30(21):2463-74.
  C21orf2 antibody [N1C2] (GTX119046)
Nat Cell Biol.
2015 Aug;17(8):1074-87.
  C9orf72 antibody (GTX119776)
Acta Neuropathol Commun.
2016 May 18;4(1):51
Sci Transl Med.

2013 Oct 23;5(208):208ra149.
Lancet Neurol.
2012 Jan;11(1):54-65.
Galectin3 antibody (GTX125897)
J Proteomics.
2016 Mar 16;136:1-12.
  HMGB1 antibody (GTX101277)
Nat Commun.
2016 Jun 22;7:11929.

Mol Cell.
2016 Mar 17;61(6):903-13.
  HSC70 antibody [C1C3] (GTX111150)
PLoS One.
2017 May 15;12(5):e0177378.

Mol Cell Proteomics.
2011 Oct;10(10):M110.007138
  SOD1 antibody (GTX100554)
PLoS One.
2016 Aug 18;11(8):e0160883
Food Funct.
2016 Oct 12;7(10):4175-4187.
SOD1 antibody (GTX100659)
Dev Neurobiol.
2014 Aug;74(8):839-50
  SQSTM1 (phospho Ser403) antibody (GTX128171)
Autophagy.
2017 Jan 2;13(1):133-148.
  SQSTM1 antibody [N3C1], Internal antibody (GTX100685)
Sci Rep.
2017 Jan 30;7:41437
Mol Cancer.
2014 Jul 15;13:172
  TDP43 antibody (GTX114210)
Mol Cell.
2016 Mar 17;61(6):903-13

Acta Neuropathol.
2016 Nov;132(5):721-738.
TBK1/NaK ATPase antibody (GTX30202)
Hum Gene Ther.
2016 Sep;27(9):712-26.
  VCP antibody [N1N2], N-term (GTX113030)
Oncol Rep.
2017 Feb;37(2):1100-1106.

J Vet Med Sci.
2016 Sep 1;78(8):1293-8
  VCP antibody (GTX101089)
Mol Cell.
2017 Jun 1;66(5):622-634.e8.

Physiol Rep.
2017 Jun;5(12). pii: e13318.
   

 

 

Highlighted Products:

KOKD Citation
C9orf72 antibody   Nek1 antibody   SOD1 antibody   TDP43 antibody

C9orf72 antibody (GTX119776) Citation

  Nek1 antibody (GTX130828)   SOD1 antibody (GTX100659) Citation   TDP43 antibody (GTX114210) Citation

 

FUS antibody [C1C3]   VCP antibody [N1N2], N-term   HSC70 antibody [N2C1], Internal   C21orf2 antibody [N1C2]

FUS antibody [C1C3] (GTX101810)

  VCP antibody [N1N2], N-term (GTX113030) Citation   HSC70 antibody [N2C1], Internal (GTX111069) Citation   C21orf2 antibody [N1C2] (GTX119046) Citation

 

KOKD Citation
  Cat. No. Product Name Clonality Reactivity Application
Citation GTX112141 alpha Tubulin 4a antibody Rb pAb Hu, Ms, Chk, Dm, Rat ICC/IF, IHC-P, WB
  GTX112653 alpha Tubulin 4a antibody Rb pAb Hu, Ms ICC/IF, WB
Citation GTX113098 alpha Tubulin 4a antibody Rb pAb Hu, Ms ICC/IF, IHC-P, WB
  GTX120076 ALS2CR12 antibody Rb pAb Hu ICC/IF, IHC-P, WB
  GTX130329 ATXN2 antibody Rb pAb Hu, Ms IHC-P, WB
  GTX130331 ATXN2 antibody Rb pAb Hu ICC/IF, WB
Citation GTX119046 C21orf2 antibody [N1C2] Rb pAb Hu ICC/IF, IHC-P, WB
Citation GTX119776 C9orf72 antibody Rb pAb Hu, Ms ICC/IF, IHC, IHC-P, WB
GTX632041 C9orf72 antibody [GT779] Ms mAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB
  GTX100231 DCTN1 antibody [C3], C-term Rb pAb Hu, Rat ICC/IF, IHC-P, WB
  GTX110048 FIG4 antibody Rb pAb Hu ICC/IF, IHC-P, WB
  GTX101810 FUS antibody [C1C3] Rb pAb Hu, Ms IHC-P, WB
GTX113486 Galectin 3 antibody Rb pAb Hu, Rat ICC/IF, IHC-P, WB
Citation GTX125897 Galectin 3 antibody Rb pAb Hu, Ms, Rat ELISA, IHC-P, WB
  GTX130498 Gemin 5 antibody Rb pAb Hu ICC/IF, IP, WB
Citation GTX101277 HMGB1 antibody Rb pAb Hu, Ms, Pig, Rat ICC/IF, IHC, IHC-P, WB
Citation GTX112959 HMGB1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB
GTX628835 HMGB1 antibody [GT348] Ms mAb Hu, Ms, Rat ICC/IF, IHC-P, WB
GTX629403 HMGB1 antibody [GT349] Ms mAb Hu, Ms, Rat ICC/IF, IHC-P, WB
  GTX101144 HSC70 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB
Citation GTX111150 HSC70 antibody [C1C3] Rb pAb Hu, Ms, Pig IHC-P, WB
Citation GTX111069 HSC70 antibody [N2C1], Internal Rb pAb Hu, Ms ICC/IF, IHC-P, WB
  GTX113057 NAK antibody [N2C1], Internal Rb pAb Hu, Ms ICC/IF, IHC-P, WB
Citation GTX30202 NaK ATPase antibody [464.6 or 6H] Ms mAb Hu, Ms, Dog, Dm, Pig, Rat, Yeast, Gpig, NHuPrm, Rb, Shp, Xl, Bov FACS, ICC/IF, IHC, WB
  GTX130828 Nek1 antibody Rb pAb Hu, Ms ICC/IF, WB
  GTX111463 Nek1 antibody Rb pAb Hu ICC/IF
  GTX105447 Optineurin antibody Rb pAb Hu ICC/IF, IHC-P, IP, WB
  GTX132575 Optineurin antibody Rb pAb Hu ICC/IF, IHC-P, WB
  GTX102005 Peripherin antibody Rb pAb Hu IHC-P, WB
  GTX120605 SCFD1 antibody [N2C1], Internal Rb pAb Hu IHC-P, WB
Citation GTX101047 SMN1 antibody Rb pAb Hu ICC/IF, WB
  GTX118263 SMNDC1 antibody [N1C3-2] Rb pAb Hu, Ms ICC/IF, IHC-P, WB
Citation GTX100554 SOD1 antibody Rb pAb Hu, Ms, Rat ELISA, ICC/IF, IHC-P, WB
Citation GTX100659 SOD1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-Fr, IHC-P, WB
  GTX133943 SQSTM1 (phospho Ser272) antibody Rb pAb Hu WB
  GTX128171 SQSTM1 (phospho Ser403) antibody Rb pAb Hu, Ms, Rat FACS, IHC-P, WB
Citation GTX111393 SQSTM1 antibody Rb pAb Hu, Ms ICC/IF, WB
Citation GTX629890 SQSTM1 antibody [GT1478] Ms mAb Hu, Ms FACS, ICC/IF, IHC-Fr, WB
GTX629888 SQSTM1 antibody [GT239] Ms mAb Hu, Rat ICC/IF, WB
Citation GTX100685 SQSTM1 antibody [N3C1], Internal Rb pAb Hu, Ms, Rat, Zfsh, Bov, Honeybee FACS, ICC/IF, IHC-P, IP, WB
GTX100579 TDP43 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB
Citation GTX114210 TDP43 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB, ChIP-seq
GTX630196 TDP43 antibody [GT225] Ms mAb Hu, Ms, Rat WB
GTX630197 TDP43 antibody [GT733] Ms mAb Hu ICC/IF, WB
Citation GTX101089 VCP antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB
Citation GTX113030 VCP antibody [N1N2], N-term Rb pAb Hu, Ms, Dog, Rat ICC/IF, IHC-P, IP, WB

 

 

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