5 Sep 2017
 
Ion channels are pore-forming, usually multimeric plasma membrane proteins that can open and close in response to chemical, temperature, or mechanical signals. An open channel allows specific ions to rapidly traverse the transmembrane passageway along an electrochemical gradient, generating an electrical signal that is propagated along excitable cells. Ion channels are of immense importance in clinical medicine as they are linked to a broad array of disorders and are targets of an ever-expanding, and commonly prescribed, armamentarium of pharmacologic agents. Nevertheless, there remains a great void in our understanding of ion channel biology, which limits our ability to develop more effective and more specific drugs.
GeneTex offers an outstanding selection of antibodies to support ion channel research. Please see the highlighted antibodies below or click here for a complete list of relevant products.

 

  HCN1 antibody (GTX131334)   DPP6 antibody (GTX133338)   IP3 Receptor I antibody (GTX133104)  
  HCN1 antibody (GTX131334)
IHC-Fr (left; Green) and IHC-P (right) analysis of HCN1 expression in mouse cerebellum.
  DPP6 antibody (GTX133338)
IHC-Fr (left; Green) and IHC-P (right) analysis of DPP6 expression in mouse hippocampus.
  IP3 Receptor I antibody (GTX133104)
IHC-Fr (left; Green) and IHC-P (right) analysis of IP3 Receptor I expression in mouse cerebellum.
 
  CACNB4(GTX100202)   VGluT1 antibody (GTX133148)   P2X7 antibody (GTX104288)  
  CACNB4(GTX100202)
IHC-Fr (left; Green) and IHC-P (right) analysis of CACNB4 expression in mouse cerebellum.
  VGluT1 antibody (GTX133148)
IHC-Fr (left; Green) and IHC-P (right) analysis of VGluT1 expression in mouse cerebellum.
  P2X7 antibody (GTX104288)
IHC-Fr (left; Green) and IHC-P (right) analysis of P2X7 expression in mouse retina (left) and rat brain (right).
 
  Cav1.2 antibody   Cav2.1 antibody   Cav3.1 antibody  
  Cav1.2 antibody (GTX54754)
IHC analysis of Cav1.2 (red) and Calbindin 28K (green) expression in mouse cerebellum.
  Cav2.1 antibody (GTX54753)
IHC analysis of Cav2.1 (red) and GFAP (green) expression in mouse cerebellum.
  Cav3.1 antibody (GTX54760)
IHC analysis of Cav3.1 expression (green) and DAPI (blue) in rat cerebellum.
 
  Cav3.2 antibody   TRPV1 antibody   TRPC6 antibody  
  Cav3.2 antibody (GTX54813)
IHC analysis of Cav3.2 expression (red) and parvalbumin staining (green) in mouse cerebellum.
  TRPV1 antibody (GTX54762)
IHC analysis of TRPV1 expression (red) and parvalbumin staining (green) in rat dorsal root ganglion.
  TRPC6 antibody (GTX54757)
IHC analysis of TRPC6 expression (red) and parvalbumin staining (green) in mouse cerebellum.
 
  Nav1.6 antibody   ASIC1 antibody   ASIC3 antibody  
  Nav1.6 antibody (GTX54842)
IHC analysis of Nav1.6 expression (green), parvalbumin staining (red) and DAPI (blue) in mouse hippocampus.
  ASIC1 antibody (GTX54804)
IHC analysis of ASIC1 expression (red) and parvalbumin staining (green) in rat brain.
  ASIC3 antibody (GTX54807)
IHC-Fr analysis of ASIC3 (red) and ASIC1 (green) expression with DAPI (blue) in rat dorsal root ganglia.
 

 

Chloride Channels citation-support  KOKD-validated
  Cat. No. Product Name Clonality Reactivity Application
  GTX100217 CLCA1 antibody [C1C2], Internal Rb pAb Hu ICC/IF,IHC-P,WB
  GTX32527 CLCN1 antibody Rb pAb Hu, Ms IHC-P, WB
GTX113403 CLCN2 antibody [C1C3] Rb pAb Hu ICC/IF, IHC-P, WB
  GTX54815 CLCN3 antibody Rb pAb Hu, Rat ICC/IF, IHC, IP, WB
  GTX53531 CLCN4 antibody Rb pAb Hu ICC/IF, IHC-P, WB
  GTX104090 CLCN5 antibody [N1C1] Rb pAb Hu WB
  GTX53963 CLCN5 antibody Rb pAb Hu, Ms, Rb IHC-P, WB
  GTX34317 CLCN6 antibody Rb pAb Hu, Ms, Mk, Rat ELISA, WB
  GTX55139 CLCN7 antibody Rb pAb Hu, Ms, Rat ICC/IF, WB
  GTX55140 CLCNKA antibody Rb pAb Hu, Rat WB
GTX47709 CLCNKB antibody, N-term Rb pAb Hu, Ms IHC, WB

 

 
 
Calcium Channels citation-support  KOKD-validated
  Cat. No. Product Name Clonality Reactivity Application
  GTX54770 Cav alpha 2/delta 2 antibody Rb pAb Hu, Ms, Rat IHC, WB
  GTX108807 Cav beta 1 antibody [C1C3] Rb pAb Hu, Ms ICC/IF, WB
  GTX54771 Cav beta 2 antibody Rb pAb Ms, Rat WB
  GTX100202 Cav beta 4 antibody [C3], C-term Rb pAb Hu, Ms ICC/IF, IHC-Fr, IHC-P, WB
GTX102941 Cav1.1 antibody [N2N3] Rb pAb Hu IHC-P, WB
  GTX22862 Cav1.1 antibody [1A] Ms mAb Hu, Ms, Rat, Fsh, Gpig, Rb Blocking, ELISA, FACS, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
  GTX54754 Cav1.2 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, IP, WB
  GTX54755 Cav1.3 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX54753 Cav2.1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX102449 Cav2.2 antibody [C3], C-term Rb pAb Hu ICC/IF, WB
  GTX54812 Cav2.2 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX54756 Cav2.3 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX54760 Cav3.1/CACNA1G antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX54813 Cav3.2 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-Fr, IP, WB
  GTX16604 Cav3.3 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX133149 IP3 Receptor I antibody Rb pAb Ms, Rat IHC-Fr, IHC-P, WB
  GTX133104 IP3 Receptor I antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-Fr, WB
GTX16613 ORAI1 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, IHC-P, WB
  GTX120952 ORAI2 antibody Rb pAb Hu IHC-P, WB
  GTX54767 ORAI2 antibody Rb pAb Hu, Rat IHC, IHC-P, WB
  GTX85442 ORAI3 antibody Rb pAb Hu, Ms, Rat ELISA, ICC/IF, WB
  GTX113558 STIM1 antibody Rb pAb Ms WB
  GTX54855 STIM1 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC-P, IP, WB
GTX85440 STIM2 antibody Rb pAb Hu, Ms, Rat ELISA, ICC/IF, IHC-P, WB
  GTX54765 TRPA1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX54859 TRPC1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-Fr, IP, WB
  GTX54761 TRPC2 antibody Rb pAb Ms, Rat WB
  GTX54860 TRPC3 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
  GTX54758 TRPC4 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-Fr, IP, WB
  GTX54861 TRPC5 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
GTX113858 TRPC6 antibody [N1N3] Rb pAb Hu, Rat WB
  GTX104730 TRPC6 antibody [C3], C-term Rb pAb Hu WB
  GTX54757 TRPC6 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, IP, WB
  GTX42022 TRPC7 antibody [S64A-36] Ms mAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
GTX112252 TRPM2 antibody [N1N2-2], N-term Rb pAb Hu, Rat IHC-P, WB
  GTX16612 TRPM3 antibody Rb pAb Hu, Ms, Rat WB
  GTX54863 TRPM4 antibody Rb pAb Hu, Ms, Rat IHC, IHC-P, WB
  GTX54864 TRPM5 antibody Rb pAb Hu, Ms, Rat IHC, IHC-P, WB
GTX16611 TRPM6 antibody Rb pAb Ms, Rat WB
GTX41997 TRPM7 antibody [S74-25] Ms mAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX104731 TRPM7 antibody [C3], C-term Rb pAb Hu IHC-P, WB
GTX23243 TRPM8 antibody Rb pAb Hu, Ms IHC-P, WB
  GTX111818 TRPM8 antibody [N2C1], Internal Rb pAb Hu WB
  GTX54762 TRPV1/VR1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
GTX101868 TRPV2/VRL1 antibody [C2C3], C-term Rb pAb Hu, Ms IHC-P, WB
  GTX54763 TRPV3 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX54764 TRPV4 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, IHC-Fr, IP, WB
  GTX109049 TRPV4 antibody [N1C1] Rb pAb Hu FACS
  GTX54868 TRPV5 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-P, WB
  GTX54869 TRPV6 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-Fr, IHC-P, IP, WB

 

 
 
Potassium Channels citation-support  KOKD-validated
  Cat. No. Product Name Clonality Reactivity Application
  GTX79456 CNG Channel antibody [CNC 9C1] Ms mAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX54787 CNGA1 antibody Rb pAb Rat WB
  GTX112498 CNGA2 antibody [C1C3] Rb pAb Hu ICC/IF, IHC-P, WB
  GTX54816 CNGA2 antibody Rb pAb Ms, Rat ICC/IF, IHC, WB
  GTX33104 CNGA3 antibody Rb pAb Hu, Ms, Rat IHC, IHC-P, WB
  GTX133338 DPP6 antibody Rb pAb Ms, Rat IHC-Fr, IHC-P, WB
  GTX131334 HCN1 antibody Rb pAb Hu, Ms, Rat IHC-Fr, IHC-P, WB
  GTX54824 HCN2 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-Fr, IP, WB
  GTX41987 HCN3 antibody [S141-28] Ms mAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX42001 HCN4 antibody [S114-10] Ms mAb Hu, Ms, Rat ICC/IF, IHC, IHC-Fr, WB
  GTX54811 KCNE1 antibody Rb pAb Ms, Rat FACS, ICC/IF, IHC, IP, WB
  GTX54783 KCNE2 / MiRP1 antibody Ms mAb Hu, Ms, Rat ICC/IF, IHC, IHC-Fr, IP, WB
  GTX16690 KCNE3 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX54775 KCNJ1 / ROMK antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX31601 KCNK1 antibody Rb pAb Ms ELISA, ICC/IF, IHC-P, WB
  GTX132622 KCNK3 antibody Rb pAb Hu, Ms WB
  GTX47694 KCNN1 antibody, C-term Rb pAb Hu WB
  GTX54829 KCNN2 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX54779 KCNN3 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX130239 KCNN4 antibody Rb pAb Hu WB
  GTX54786 KCNN4 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX54839 KCNQ1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX60528 KCNQ1 antibody [5E12] Ms mAb Hu ELISA, FACS, WB
  GTX54840 KCNQ2 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX54782 KCNQ3/Kv7.3 antibody Rb pAb Ms, Rat ICC/IF, IHC, IP, WB
  GTX41990 KCNQ4 antibody [S43-6] Ms mAb Hu, Ms, Rat ICC/IF, IHC-Fr, IP, WB
  GTX106198 KCNQ5 antibody [N3C2], Internal Rb pAb Hu WB
  GTX54793 KCNQ5 antibody Rb pAb Hu, Ms, Rat IHC, IHC-Fr, WB
  GTX54830 Kir2.1 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, IP, WB
  GTX41992 Kir2.2 antibody [S124B-38] Ms mAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX16644 Kir2.3 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
GTX108745 Kir3.1/GIRK1 antibody [N3C3] Rb pAb Hu, Ms IHC-P, WB
GTX54831 Kir3.1/GIRK1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX54832 Kir3.2/GIRK2 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-Fr, IP, WB
  GTX87115 Kir3.3/KCNJ9 antibody Rb pAb Hu, Ms, Rat ELISA, WB
  GTX54780 Kir3.4 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX54781 Kir4.1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX54833 Kir6.1 antibody Rb pAb Hu, Ms, Rat IHC, IP, WB
  GTX54777 Kir6.2 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX16698 Kir7.1 antibody Rb pAb Hu, Ms, Rat FACS, IHC, IHC-P, WB
  GTX54834 Kv1.1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX54835 Kv1.2 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-Fr, WB
  GTX16679 Kv1.3 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, WB
  GTX54836 Kv1.4 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX54837 Kv1.5 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX16716 Kv1.5 antibody Rb pAb Hu, Rat FACS, IHC, WB
  GTX132559 Kv1.5 antibody Rb pAb Hu WB
  GTX47650 Kv1.7/KCNA7 antibody, C-term Rb pAb Hu WB
  GTX54788 Kv10.1/KCNH1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX16654 Kv10.2/KCNH5 antibody Rb pAb Hu, Rat IHC, WB
  GTX54789 Kv11.1 antibody Rb pAb Hu, Rat FACS, ICC/IF, IHC, IP, WB
  GTX131149 KCNV2 antibody Rb pAb Hu WB
  GTX16688 Kv11.2/KCNH6 antibody Rb pAb Hu, Ms, Rat IHC, WB
  GTX123026 Kv11.3/KCNH7 antibody [N1N2], N-term Rb pAb Hu WB
  GTX16686 Kv11.3/KCNH7 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX16687 Kv12.1 antibody Rb pAb Rat WB
  GTX47445 Kv12.2/KCNH3 antibody, Internal Rb pAb Hu WB
  GTX54790 Kv12.3 antibody Rb pAb Hu, Rat IHC, IHC-P, WB

 

Sodium Channels citation-support  KOKD-validated
  Cat. No. Product Name Clonality Reactivity Application
  GTX87930 Sodium Channel-pan antibody Rb pAb Hu, Ms, Rat ELISA, IHC, IHC-P, WB
  GTX105373 ASIC1 antibody [N1C2] Rb pAb Hu WB
  GTX54804 ASIC1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX80490 ASIC2/ACCN1 antibody, Internal Rb pAb Hu FACS, IHC-P, WB
  GTX54807 ASIC3 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-Fr, WB
  GTX116235 ASIC4/ACCN4 antibody [N1N3] Rb pAb Hu WB
  GTX110436 ENaC Alpha antibody [N3C2], Internal Rb pAb Hu IHC-P, WB
  GTX41971 ENaC Beta antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX49367 ENaC Gamma antibody [11-35-1] Ms mAb Hu ELISA, ICC/IF, IHC-F, IHC-P, WB
  GTX54808 NALCN antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX54841 Nav1.1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX54797 Nav1.2 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IP, WB
  GTX16937 Nav1.3/SCN3A antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-Fr, IP, WB
  GTX16970 Nav1.4/SCN4A antibody Rb pAb Hu, Ms, Rat WB
  GTX54798 Nav1.5 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-P, IP, WB
  GTX54842 Nav1.6 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX54800 Nav1.7 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
  GTX54806 Nav1.9 antibody Rb pAb Hu, Rat ICC/IF, IHC, IHC-Fr, WB
  GTX87701 Nav2.1/SCN7A antibody Rb pAb Hu ELISA, ICC/IF
  GTX16973 SCN1B antibody Rb pAb Ms, Rat ICC/IF, IHC, WB
  GTX54799 SCN2B/Nav beta 2 antibody Rb pAb Hu, Ms, Rat IHC, WB
GTX104440 SCN3B antibody [N1C3] Rb pAb Hu WB
  GTX54810 SCN4B antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB

 

Membrane Receptors citation-support  KOKD-validated
Class   Cat. No. Product Name Clonality Reactivity Application
Catalytic Receptor   GTX54856 TrkA antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, IHC-Fr, WB
  GTX132966 TrkA antibody Rb pAb Hu WB
GTX54857 TrkB antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, IHC-Fr, WB
  GTX133722 TrkB antibody Rb pAb Ms WB
  GTX54858 TrkC antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-Fr, WB
P2XY Receptors   GTX16925 P2X1 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, WB
  GTX108534 P2X2 antibody [C3], C-term Rb pAb Hu, Ms ICC/IF, IHC-P, WB
GTX117217 P2X3 antibody [N3C3] Rb pAb Hu ICC/IF, IHC-P, WB
  GTX54851 P2X4 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, IP, WB
  GTX108504 P2X5 antibody [C3], C-term Rb pAb Hu ICC/IF, IHC-P, WB
  GTX16843 P2X6 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, WB
  GTX104288 P2X7 antibody Rb pAb Hu, Ms, Rat IHC-Fr, IHC-P
  GTX16924 P2Y1 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, WB
  GTX114609 P2Y2 antibody [N3C3] Rb pAb Hu, Ms, Rat IP, WB
  GTX16815 P2Y4 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, IP, WB
  GTX16829 P2Y6 antibody Rb pAb Hu, Ms, Rat FACS, ICC/IF, IHC, IP, WB
GTX108169 P2Y7/Leukotriene B4 Receptor  antibody [N1], N-term Rb pAb Hu WB
GTX108241 P2Y11 antibody [C2C3], C-term Rb pAb Hu WB
  GTX108143 P2Y12 antibody [N1], N-term Rb pAb Hu WB
Transporters   GTX54821 Ferroportin 1 antibody Rb pAb Hu, Ms, Rat WB
  GTX133148 VGluT1 antibody Rb pAb Ms, Rat IHC-Fr, IHC-P, WB
  GTX133142 VGluT2 antibody Rb pAb Ms, Rat WB
  GTX54871 VGluT2 antibody Rb pAb Hu, Ms, Rat IHC-Fr, WB
  GTX54872 VGluT3 antibody Rb pAb Ms, Rat IHC-Fr, WB