Conformation-specific beta-Amyloid antibody for Alzheimer's disease research
Alzheimer’s disease (AD) pathogenesis is widely believed to be driven by the production and deposition of neurotoxic β-Amyloid peptide (Aβ) aggregates that form plaques in the brain. The Aβ molecules are generated from Amyloid Precursor Protein (APP) via β- and γ- secretase cleavage to produce Aβ monomers. Most of the Aβ peptides are 40 amino acids in length (Aβ 1-40, Aβ40), with a small percentage containing 42 residues (Aβ 1-42, Aβ42). These additional two C-terminal amino acids in Aβ42 confer a greater tendency to misfold and subsequently aggregate. Thus, Aβ42 is considered to be more neurotoxic than Aβ40.
GeneTex’s “beta-Amyloid (1-42) antibody – Conformation-Specific (GTX134510)” against Aβ 1-42 oligomers can specifically detect amyloid plaques in the AD brain by IHC-P analysis. The superior specificity and sensitivity of GTX134510 were confirmed by dot blot and side-by-side IHC-P comparison.
 
beta-Amyloid (1-42) antibody – Conformation-Specific (GTX134510)
    Human Aβ (1-42) oligomer immunogen
    Validated for dot blot, IHC-P, and ELISA
    High affinity and specificity
    Low background staining
    Detects beta-Amyloid aggregates in human AD brain tissue by IHC-P
    Detects beta-Amyloid aggregates in mouse AD model brain tissue by IHC-P
 
beta-Amyloid (1-42) antibody –Conformation-Specific   beta-Amyloid (1-42) antibody –Conformation-Specific   beta-Amyloid (1-42) antibody –Conformation-Specific
Dot blot analysis of beta-Amyloid peptide (1-42) oligomers or monomers, using beta-Amyloid (1-42) antibody –Conformation-Specific (GTX134510).   beta-Amyloid (1-42) antibody –Conformation-Specific (GTX134510) detects beta-Amyloid plaques by IHC-P analysis in occipital lobe tissue from a brain with Alzheimer's disease, but not in normal human brain tissue.   beta-Amyloid (1-42) antibody –Conformation-Specific (GTX134510) detects beta-Amyloid plaques by IHC-P analysis in hippocampal tissue from a 3xTg-AD transgenic mouse brain.
beta-Amyloid (1-42) antibody –Conformation-Specific   beta-Amyloid (1-42) antibody –Conformation-Specific
Side-by-side IHC-P comparison of two conformation-specific beta-Amyloid antibodies in occipital lobe (left) or postcentral gyrus (right) tissues from human brains with Alzheimer's disease (1:500 dilution). Only GeneTex’s beta-Amyloid (1-42) antibody –Conformation-Specific (GTX134510) is able to detect beta-Amyloid plaques in the samples. * The competitor is not affiliated with GeneTex and does not endorse this product.
 
Selected Products for APP/β-Amyloid peptide (Aβ) Pathway
  Cat. No. Product Name Clonality Reactivity Applications  
Conformation-Specific Aβ GTX134510 beta Amyloid (1-42) antibody – Conformation Specific Rb pAb Hu, Ms Dot, ELISA, IHC-P Comparable Abs
APP GTX101336 APP antibody [C2C3], C-term Rb pAb Hu, Ms, Rat ICC/IF, IHC, IHC-P, WB citation
GTX112677 APP antibody Rb pAb Hu, Ms, Rat ELISA, ICC/IF, IHC-P, WB  
GTX40068 beta Amyloid (1-40) antibody [BDI350] Ms mAb Hu ELISA, ICC/IF, WB  
GTX44420 beta Amyloid (1-42) antibody [BDI780] Ms mAb Hu ELISA, ICC/IF, WB  
β Secretase GTX103757 BACE1 antibody [N1C2] Rb pAb Hu, Ms, Rat IHC-P, WB citation
GTX113319 BACE1 antibody [N1C1] Rb pAb Hu, Ms IHC-P, WB  
GTX113951 BACE2 antibody [C1C3] Rb pAb Hu, Rat ICC/IF, IHC-P, WB citation
γ Secretase GTX101028 Presenilin 1 antibody [C1C3] Rb pAb Hu, Ms, Rat IHC-P, WB  
GTX116016 Presenilin 1 antibody [C1C2], Internal Rb pAb Hu, Ms ICC/IF, IHC-P, WB  
GTX15549 Presenilin 2 antibody [APS 26] Ms mAb Hu, Ms, Rat, NHuPrm ELISA, ICC/IF, IHC-P, IP, WB  
GTX115930 Nicastrin antibody Rb pAb Hu ICC/IF, WB  
GTX79306 APH-1 antibody Rb pAb Hu, Ms, Hm, NHuPrm ICC/IF, IP, WB, ChIP assay  
GTX85063 PEN2 antibody Rb pAb Hu, Ms, Rat ELISA, IHC-P, WB