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Cancer Metabolism

23 March 2016

 

Nearly a century ago, Otto Warburg found that cancer cells can shift their energy production to aerobic glycolysis instead of the more efficient oxidative phosphorylation. An emerging hallmark of many cancers is their metabolic plasticity, as rewiring of cancer cells' metabolic fluxes is essential for their proliferative and invasive agenda. With increasing understanding of these alterations, researchers are identifying features of tumor metabolism that can be used for novel diagnostic, prognostic, and therapeutic opportunities.
Glycolysis | Amino Acid Metabolism | Lipid Metabolism

 

 

Highlighted Products

 
IDH1 antibody [GT1521]   IDH2 antibody [GT673]   LDHA antibody   Hexokinase 1 antibody

IDH1 antibody [GT1521] (GTX629818)

  

IDH2 antibody [GT673] (GTX628487)

  

LDHA antibody (GTX101416)

  

Hexokinase 1 antibody (GTX105248)

 

PKM antibody   Pyruvate Dehydrogenase E1 alpha antibody   Pyruvate Dehydrogenase E1 beta subunit antibody   SDHB antibody [C2C3], C-term

PKM antibody (GTX107977)

  

Pyruvate Dehydrogenase E1 alpha antibody (GTX104015)

  

Pyruvate Dehydrogenase E1 beta subunit antibody (GTX104040)

  

SDHB antibody [C2C3], C-term (GTX104628)

 

Glutaminase C antibody   Arginase 1 antibody   Monoglyceride lipase antibody   Fatty Acid Synthase antibody [N1], N-term

Glutaminase C antibody (GTX131263)

  

Arginase 1 antibody (GTX109242)

  

Monoglyceride lipase antibody (GTX103517)

  

Fatty Acid Synthase antibody [N1], N-term (GTX109833)

 

 

Representative Products

Cancer-related Glycolysis Citation Citation
  Cat. No. Product Name Clonality Reactivity Application
Citation GTX109877 Fumarate hydratase antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB
  GTX84497 Fumarate hydratase antibody [1F10] Ms mAb Hu, Dog, Rat FACS, ICC/IF, IHC, IHC-P, WB
  GTX630146 Fumarate hydratase antibody [GT7612] Ms mAb Hu, Ms, Rat ICC/IF, WB
Citation GTX100118 GAPDH antibody Rb pAb Hu, Ms, Dog, Dm, Rat, E. coli ICC/IF, IHC-P, IP, WB, IHC-R, IB
Citation GTX627408 GAPDH antibody [GT239] Ms mAb Hu, Ms, Dm, Rat, Zfsh, Yeast ICC/IF, IHC-P, WB
Citation GTX100684 GluT1 antibody [C3], C-term Rb pAb Hu ICC/IF, WB
  GTX105248 Hexokinase 1 antibody Rb pAb Hu ICC/IF, IHC-P, WB
  GTX82790 Hexokinase 1 antibody [3A10] Ms mAb Hu, Ms, Rat ELISA, FACS, ICC/IF, IHC, IHC-P, WB
  GTX111525 Hexokinase II antibody Rb pAb Hu, Ms ICC/IF, IHC-P, WB
  GTX84357 Hexokinase II antibody [4C5] Ms mAb Hu, Dog FACS, ICC/IF, IHC, IHC-P, WB
  GTX107822 Hexokinase III antibody [C1C3] Rb pAb Hu IHC-P, WB
  GTX111409 Hexokinase III antibody [C1C3-2] Rb pAb Hu ICC/IF, WB
Citation GTX127309 HIF1 alpha antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB, ChIP assay
  GTX629818 IDH1 antibody [GT1521] Ms mAb Hu, Ms, Rat ICC/IF, IP, WB
  GTX628487 IDH2 antibody [GT673] Ms mAb Hu, Ms, Rat ICC/IF, IHC-P, WB
  GTX101416 LDHA antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB
  GTX117793 MCTS1 antibody [N1C3] Rb pAb Hu, Ms, Rat IHC-P, WB
  GTX87926 MOT4 antibody Rb pAb Hu, Ms, Rat ELISA, WB
Citation GTX107405 PDK1 antibody Rb pAb Hu, Ms ICC/IF, IP, WB
  GTX104286 PDK3 antibody [N1C2] Rb pAb Hu ICC/IF, IHC-P
  GTX81596 PDK4 antibody, Internal Rb pAb Hu ELISA, ICC/IF, IHC, IHC-P, WB
  GTX109533 PDP 1 antibody [N1N3] Rb pAb Ms WB
  GTX111597 PFK (muscle) antibody [C1C3] Rb pAb Hu, Ms ICC/IF, WB
  GTX107857 PFK (platelet) antibody [N3C3] Rb pAb Hu, Ms WB
  GTX108335 PFKFB3 antibody [C3], C-term Rb pAb Hu IHC-P, IP, WB
  GTX105697 PFKL antibody [C1C3] Rb pAb Hu, Ms ICC/IF, IHC-P, WB
  GTX629745 PGAM1 antibody [GT256] Ms mAb Hu, Ms, Rat WB
  GTX114633 PGAM1 antibody [N1C3] Rb pAb Hu, Ms WB
  GTX101948 PHGDH antibody [N1N2], N-term Rb pAb Hu, Ms ICC/IF, IHC-P, IP, WB
Citation GTX107977 PKM antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB
  GTX54577 Pyruvate Carboxylase antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC, WB
Citation GTX104015 Pyruvate Dehydrogenase E1 alpha antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB
  GTX104040 Pyruvate Dehydrogenase E1 beta subunit antibody Rb pAb Hu, Ms, Rat IHC-P, WB
  GTX111536 Pyruvate Kinase (liver/RBC) antibody Rb pAb Hu, Rat ICC/IF, IHC-P, WB
Citation GTX101688 SDHA antibody [C1C3] Rb pAb Hu, Ms IHC-P, WB
  GTX632636 SDHA antibody [GT20710] Ms mAb Hu WB
  GTX113833 SDHB antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB
Citation GTX104628 SDHB antibody [C2C3], C-term Rb pAb Hu, Ms ICC/IF, IHC-P, WB
  GTX88031 SLC2A4 / GLUT4 antibody, C-term Gt pAb Ms, Rat WB
  GTX110514 TIGAR antibody [C2C3], C-term Rb pAb Hu IHC-P, WB

 

Cancer-related Amino Acid Metabolism Citation Citation
  Cat. No. Product Name Clonality Reactivity Application
　 GTX113945 PAD4 antibody Rb pAb Hu, Ms ICC/IF, IHC-P, WB, ChIP assay
　 GTX101344 ASS1 antibody Rb pAb Hu IHC-P, WB
　 GTX89088 Argininosuccinate synthetase 1 antibody, Internal Gt pAb Hu, Bov ICC/IF, IHC, IHC-P, IP, WB
Citation GTX109242 Arginase 1 antibody Rb pAb Hu, Ms FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB
　 GTX113753 IDO1 antibody [N1N3] Rb pAb Hu ICC/IF, WB
Citation GTX114831 TDO2 antibody [N1C1] Rb pAb Hu WB
　 GTX109027 Tryptophan Hydroxylase antibody Rb pAb Hu ICC/IF, WB
　 GTX131263 Glutaminase C antibody Rb pAb Hu, Ms ICC/IF, IHC-P, IP, WB
　 GTX632317 Glutaminase C antibody [GT3211] Ms mAb Hu ICC/IF, WB
Citation GTX81012 GLS antibody, C-term Rb pAb Hu, Ms FACS, ICC/IF, IHC-P, WB
　 GTX46480 BCAT1 antibody, N-term Rb pAb Hu WB
　 GTX104121 BCAT2 antibody Rb pAb Hu, Ms IHC-P, WB
Citation GTX105765 Glutamate Dehydrogenase antibody Rb pAb Hu, Ms ELISA, ICC/IF, IHC-P, WB
Citation GTX89973 ATF4 antibody, C-term Gt pAb Hu, Ms, Rat WB
Citation GTX101943 ATF4 antibody Rb pAb Hu, Rat ICC/IF, WB
　 GTX30070 ATF4 antibody Rb pAb Hu, Ms, Rat IHC-P, WB
　 GTX103195 SHMT1 antibody Rb pAb Hu WB
Citation GTX125939 SHMT2 antibody Rb pAb Hu ICC/IF, IHC-P, WB
　 GTX46481 SHMT2 antibody, C-term Rb pAb Hu, Ms, Dog, Rat IHC, WB
　 GTX46482 SHMT2 antibody, N-term Rb pAb Hu, Ms, Dog, Rat IHC, WB
　 GTX110576 PSAT1 antibody [N1C3] Rb pAb Hu, Ms ICC/IF, IHC-P, WB
　 GTX115909 PSAT1 antibody [N3C3] Rb pAb Hu, Ms ICC/IF, IHC-P, WB
　 GTX109163 PSPH antibody Rb pAb Hu ICC/IF, WB
Citation GTX103322 NRF2 antibody [N2C2], Internal Rb pAb Hu, Rat ICC/IF, IHC-P, IP, WB, ChIP assay

 

Cancer-related Lipid Metabolism  
Cat. No. Product Name Clonality Reactivity Application
GTX112387 ATP citrate lyase antibody [N1N2], N-term Rb pAb Hu ICC/IF, IHC-P, WB
GTX109833 Fatty Acid Synthase antibody [N1], N-term Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB
GTX629761 Fatty Acid Synthase antibody [GT5210] Ms mAb Hu WB
GTX54088 HMGCR antibody Rb pAb Hu, Ms ICC/IF, IHC-P, WB
GTX83326 AMACR antibody [2A10F3] Ms mAb Hu, Ms ELISA, ICC/IF, IHC-P, WB
GTX53954 CPT1A antibody Rb pAb Hu, Ms, Rb ICC/IF, IHC-P, WB
GTX59676 ATGL antibody Rb pAb Hu, Ms, Rat IP, WB
GTX53688 ATGL antibody [AT2G2] Ms mAb Hu, Ms ELISA, IHC, IHC-P, WB
GTX103517 Monoglyceride lipase antibody Rb pAb Hu, Ms, Rat IHC-P, WB


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