| Catalog Number | GTX100320 |
| Product Name | GALR2 antibody |
| Full Name | galanin receptor 2 |
| Product Description | Rabbit polyclonal antibody to GALR2 (galanin receptor 2) |
| Synonyms | GALNR2 | MGC125983 | MGC125984 |
| Background | Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq] |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Synthetic peptide contain a sequence corresponding to a region within amino acids 212 and 277 of Human GALR2 |
| Antigen Species | Human |
| Tested Applications | WB. The usefulness of this product in other applications has not been determined. |
| Application Note | Suggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
| Specificity | This antibody is specific to the Human GALR2 protein. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | 293T | A431 | H1299 | HeLaS3 | HepG2 | Molt-4 | Raji |
| Target | GALR2 |
| Predicted Target Size(KDa) | 41.7 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Form Supplied | Liquid |
| Concentration | 1 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |