click picture to see original size GTX110434 WB Image
Sample (30 ug of whole cell lysate)
A:H1299
7.5 % SDS PAGE
GTX110434 diluted at 1:1000

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Product Information




Catalog NumberGTX110434
Product NameFactor XIIIa antibody
Full Namecoagulation factor XIII, A1 polypeptide
Product DescriptionRabbit polyclonal antibody to F13A1 (coagulation factor XIII, A1 polypeptide)
SynonymsF13A
BackgroundThis gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq]
ClonalityPolyclonal
HostRabbit
ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 228 of Human F13A1
Antigen SpeciesHuman
Tested ApplicationsWB. The usefulness of this product in other applications has not been determined.
Application NoteSuggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
SpecificityThis antibody is specific to the Human F13A1 protein.
Species Cross ReactivityHuman - Not yet tested in other species
Positive ControlsH1299
TargetF13A1
Predicted Target Size(KDa)83.28
Cellular LocalizationCytoplasm | Secreted
Form SuppliedLiquid
Concentration1 mg/ml
PurificationPurified by antigen-affinity chromatography.
Storage Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage InstructionKeep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Factor XIIIa antibody
GTX110434
USD $289.00

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