click picture to see original size GTX110558 WB Image
Sample (30 ug of whole cell lysate)
A: A431 (GTX27909)
B: Hela
C: Molt-4 (GTX27912)
10% SDS PAGE
GTX110558 diluted at 1:1000

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Product Information




Catalog NumberGTX110558
Product NameAPE1 antibody
Full NameAPEX nuclease (multifunctional DNA repair enzyme) 1
Product DescriptionRabbit polyclonal antibody to APEX1 (APEX nuclease (multifunctional DNA repair enzyme) 1)
SynonymsAPE | APE-1 | APE1 | APEN | APEX | APX | HAP1 | REF-1 | REF1
BackgroundApurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq]
ClonalityPolyclonal
HostRabbit
ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 302 of Human APEX1
Antigen SpeciesHuman
Tested ApplicationsWB. The usefulness of this product in other applications has not been determined.
Application NoteSuggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
SpecificityThis antibody is specific to the Human APEX1 protein.
Species Cross ReactivityHuman - Not yet tested in other species
Positive Controls293T︱A431︱H1299︱HeLa︱HepG2︱Molt-4︱Raji
TargetAPEX1
Predicted Target Size(KDa)35.56
Cellular LocalizationNucleus
Form SuppliedLiquid
Concentration1 mg/ml
PurificationPurified by antigen-affinity chromatography.
Storage Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage InstructionKeep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

APE1 antibody
GTX110558
USD $289.00

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