click picture to see original size GTX108827 WB Image
Sample (30 ug of whole cell lysate)
A: Hep G2 (GTX27900)
7.5% SDS PAGE
GTX108827 diluted at 1:1000

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Product Information

Product NameCat NoPackagePriceSpecial Price
ACTR-I antibodyGTX108827100μlUSD $289.00 -
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Catalog NumberGTX108827
Product NameACTR-I antibody
Full Nameactivin A receptor, type I
Product DescriptionRabbit polyclonal antibody to ACVR1 (activin A receptor, type I)
SynonymsACTRI | ACVR1A | ACVRLK2 | ALK2 | FOP | SKR1 | TSRI
BackgroundActivins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq]
ClonalityPolyclonal
HostRabbit
ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 125 and 505 of Human ACVR1
Antigen SpeciesHuman
Tested ApplicationsWB. The usefulness of this product in other applications has not been determined.
Application NoteSuggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
SpecificityThis antibody is specific to the Human ACVR1 protein.
Species Cross ReactivityHuman - Not yet tested in other species
Positive ControlsA431 | HeLa | HepG2 | Raji
TargetACVR1
Predicted Target Size(KDa)57.16
Cellular LocalizationMembrane
Form SuppliedLiquid
Concentration0.41 mg/ml
PurificationPurified by antigen-affinity chromatography.
Storage Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage InstructionKeep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

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