| Catalog Number | GTX101557 |
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| Product Name | mTOR antibody |
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| Full Name | FK506 binding protein 12-rapamycin associated protein 1 |
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| Synonyms | MTOR|FLJ44809|FRAP|FRAP1|FRAP2|RAFT1|RAPT1|mechanistic target of rapamycin (serine/threonine kinase) |
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| Product Description | Rabbit polyclonal antibody to mTOR (FK506 binding protein 12-rapamycin associated protein 1) |
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| Background | The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq] |
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| Host | Rabbit |
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| Clonality | Polyclonal |
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| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 2386 and 2547 of Human mTOR |
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| Antigen Species | Human |
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| Species Cross Reactivity | Human - Not yet tested in other species |
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| Predicted Cross Reactivity Species | mouse(99%), rat(100%), zebra fish(90%) |
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| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
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| Application Note | Suggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
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| Positive Controls | 293T | A431 | H1299 | HeLa | HepG2 | Raji |
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| Target | mTOR |
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| Predicted Target Size(KDa) | 289 |
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| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side | Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side | Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side |
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| Form Supplied | Liquid |
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| Concentration | 0.32 mg/ml |
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| Purification | Purified by antigen-affinity chromatography. |
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| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
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| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
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| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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