| Catalog Number | GTX101599 |
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| Product Name | ADAM15 antibody |
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| Full Name | ADAM metallopeptidase domain 15 |
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| Synonyms | ADAM15|MDC15|ADAM metallopeptidase domain 15 |
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| Product Description | Rabbit polyclonal antibody to ADAM15 (ADAM metallopeptidase domain 15) |
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| Background | The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] |
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| Host | Rabbit |
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| Clonality | Polyclonal |
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| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 225 of ADAM15 |
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| Antigen Species | Human |
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| Species Cross Reactivity | Human and mouse - Not yet tested in other species |
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| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
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| Application Note | Suggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
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| Positive Controls | HeLa | HepG2 | Molt-4 | NIH-3T3 |
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| Target | ADAM15 |
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| Predicted Target Size(KDa) | 93 |
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| Post-translation modification | Disulfide bond | Phosphoprotein | Cleavage on pair of basic residues | Glycoprotein | Zymogen | |
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| Cellular Localization | Membrane |
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| Form Supplied | Liquid |
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| Concentration | 0.35 mg/ml |
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| Purification | Purified by antigen-affinity chromatography. |
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| Storage Buffer | 1XPBS, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
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| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
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| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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