| Catalog Number | GTX100317 |
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| Product Name | SIRT1 antibody |
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| Full Name | sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) |
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| Synonyms | SIRT1|SIR2L1|sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) |
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| Product Description | Rabbit Polyclonal SIRT1 antibody ( sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)) |
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| Background | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq] |
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| Host | Rabbit |
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| Clonality | Polyclonal |
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| Immunogen | Synthetic peptide contain a sequence corresponding to a region within amino acids 595 and 610 of SIRT1 |
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| Antigen Species | Human |
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| Species Cross Reactivity | human - Not yet tested in other species |
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| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
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| Application Note | Suggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
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| Positive Controls | MCF-7 |
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| Predicted Target Size(KDa) | 82 |
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| Cellular Localization | 0 |
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| Form Supplied | Liquid |
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| Concentration | 0.45 mg/ml |
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| Purification | Purified by antigen-affinity chromatography. |
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| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
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| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
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| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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