| Catalog Number | GTX100383 |
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| Product Name | GIPR antibody |
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| Full Name | gastric inhibitory polypeptide receptor |
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| Synonyms | GIPR|MGC126722|gastric inhibitory polypeptide receptor |
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| Product Description | Rabbit polyclonal antibody to GIPR (gastric inhibitory polypeptide receptor) |
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| Background | Gastric inhibitory polypeptide (GIP; MIM 137240), also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.[supplied by OMIM] |
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| Host | Rabbit |
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| Clonality | Polyclonal |
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| Immunogen | Synthetic peptide contain a sequence corresponding to a region within amino acids 360 and 423 of Human GIPR |
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| Antigen Species | Human |
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| Species Cross Reactivity | Human - Not yet tested in other species |
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| Application Note | Antibody reactive against peptide, detects immunogen. Further validation in progress. |
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| Positive Controls | Synthetic peptide: 1:8,000 |
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| Target | GIPR |
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| Predicted Target Size(KDa) | 53 |
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| Cellular Localization | Cell membrane; Multi-pass membrane protein |
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| Form Supplied | Liquid |
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| Concentration | 1 mg/ml |
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| Purification | Purified by antigen-affinity chromatography. |
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| Storage Buffer | 1XPBS, 50% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
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| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
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| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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