| Catalog Number | GTX101474 |
|---|
| Product Name | TPN antibody |
|---|
| Full Name | TAP binding protein (tapasin) |
|---|
| Synonyms | TAPBP|NGS17|TAPA|TPN|TPSN|TAP binding protein (tapasin) |
|---|
| Product Description | Rabbit polyclonal antibody to TPN (TAP binding protein (tapasin)) |
|---|
| Background | This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq] |
|---|
| Host | Rabbit |
|---|
| Clonality | Polyclonal |
|---|
| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 221 and 407 of Human TPN |
|---|
| Antigen Species | Human |
|---|
| Species Cross Reactivity | Human - Not yet tested in other species |
|---|
| Predicted Cross Reactivity Species | cow(86%), dogs(81%) |
|---|
| Application Note | Antibody reactive against recombinant protein, detects immunogen. Further validation in progress. |
|---|
| Positive Controls | Target recombinant protein |
|---|
| Target | TPN |
|---|
| Predicted Target Size(KDa) | 48 |
|---|
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass type I membrane protein (Probable) | Microsome membrane; Single-pass membrane protein |
|---|
| Form Supplied | Liquid |
|---|
| Concentration | 2 mg/ml |
|---|
| Purification | Affinity purified by Protein A. |
|---|
| Storage Buffer | 1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
|---|
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
|---|
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
|---|