| Catalog Number | GTX104027 |
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| Product Name | GABA A Receptor alpha 1 antibody |
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| Full Name | gamma-aminobutyric acid (GABA) A receptor, alpha 1 |
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| Synonyms | GABRA1|ECA4|EJM|EJM5|gamma-aminobutyric acid (GABA) A receptor, alpha 1 |
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| Product Description | Rabbit polyclonal antibody to GABA A Receptor alpha 1 (gamma-aminobutyric acid (GABA) A receptor, alpha 1) |
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| Background | This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq] |
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| Host | Rabbit |
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| Clonality | Polyclonal |
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| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 231 of GABA A Receptor alpha 1 |
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| Antigen Species | Human |
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| Species Cross Reactivity | human - Not yet tested in other species |
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| Predicted Cross Reactivity Species | mouse(99%), rat(81%), cow(100%), zebra fish(89%) |
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| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
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| Application Note | Suggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
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| Positive Controls | NT2D1 | IMR32 |
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| Target | GABA A Receptor alpha 1 |
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| Predicted Target Size(KDa) | 52 |
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| Cellular Localization | Cell junction | synapse | postsynaptic cell membrane; Multi-pass membrane protein | Cell membrane; Multi-pass membrane protein |
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| Form Supplied | Liquid |
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| Concentration | 0.75 mg/ml |
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| Purification | Purified by antigen-affinity chromatography. |
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| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
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| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
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| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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