| Catalog Number | GTX104854 |
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| Product Name | BAG4 antibody |
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| Full Name | BCL2-associated athanogene 4 |
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| Synonyms | BAG4|BAG-4|SODD|BCL2-associated athanogene 4 |
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| Product Description | Rabbit polyclonal antibody to BAG4 (BCL2-associated athanogene 4) |
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| Background | The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. [provided by RefSeq] |
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| Host | Rabbit |
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| Clonality | Polyclonal |
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| Immunogen | Synthetic peptide contain a sequence corresponding to a region within amino acids 1 and 15 of Human BAG4 |
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| Antigen Species | Human |
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| Species Cross Reactivity | Human - Not yet tested in other species |
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| Application Note | Antibody reactive against peptide, detects immunogen. Further validation in progress. |
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| Positive Controls | Synthetic peptide: 1:8,000 |
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| Target | BAG4 |
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| Predicted Target Size(KDa) | 50 |
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| Cellular Localization | Cytoplasm |
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| Form Supplied | Liquid |
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| Concentration | 0.42 mg/ml |
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| Purification | Purified by antigen-affinity chromatography. |
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| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
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| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
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| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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