| Catalog Number | GTX105038 |
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| Product Name | alpha-dystroglycan antibody |
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| Full Name | dystroglycan 1 (dystrophin-associated glycoprotein 1) |
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| Synonyms | DAG1|156DAG|A3a|AGRNR|DAG|dystroglycan 1 (dystrophin-associated glycoprotein 1) |
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| Product Description | Rabbit polyclonal antibody to alpha-dystroglycan (dystroglycan 1 (dystrophin-associated glycoprotein 1)) |
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| Background | Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. [provided by RefSeq] |
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| Host | Rabbit |
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| Clonality | Polyclonal |
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| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 471 and 722 of Human alpha-dystroglycan |
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| Antigen Species | Human |
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| Species Cross Reactivity | Human - Not yet tested in other species |
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| Predicted Cross Reactivity Species | mouse(92%), rabbit(94%), cow(93%), cat(95%), dogs(92%) |
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| Application Note | Antibody reactive against recombinant protein, detects immunogen. Further validation in progress. |
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| Positive Controls | Target recombinant protein |
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| Target | alpha-dystroglycan |
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| Predicted Target Size(KDa) | 98 |
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| Cellular Localization | Alpha-dystroglycan: Secreted | extracellular space | Beta-dystroglycan: Cell membrane | Cytoplasm | cytoskeleton |
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| Form Supplied | Liquid |
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| Concentration | 0.66 mg/ml |
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| Purification | Purified by antigen-affinity chromatography. |
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| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
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| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
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| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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