| Catalog Number | GTX107867 |
|---|
| Product Name | ZAP70 antibody |
|---|
| Full Name | zeta-chain (TCR) associated protein kinase 70kDa |
|---|
| Synonyms | ZAP70|FLJ17670|FLJ17679|SRK|STD|TZK|ZAP-70|zeta-chain (TCR) associated protein kinase 70kDa |
|---|
| Product Description | Rabbit polyclonal antibody to ZAP70 (zeta-chain (TCR) associated protein kinase 70kDa) |
|---|
| Background | This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq] |
|---|
| Host | Rabbit |
|---|
| Clonality | Polyclonal |
|---|
| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 221 and 488 of Human ZAP70 |
|---|
| Antigen Species | Human |
|---|
| Species Cross Reactivity | Human - Not yet tested in other species |
|---|
| Predicted Cross Reactivity Species | mouse(92%), rat(91%) |
|---|
| Application Note | Antibody reactive against recombinant protein, detects immunogen. Further validation in progress. |
|---|
| Positive Controls | Target recombinant protein |
|---|
| Target | ZAP70 |
|---|
| Predicted Target Size(KDa) | 56 |
|---|
| Cellular Localization | Cytoplasm (By similarity) |
|---|
| Form Supplied | Liquid |
|---|
| Concentration | 0.62 mg/ml |
|---|
| Purification | Purified by antigen-affinity chromatography. |
|---|
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
|---|
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
|---|
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
|---|