| Catalog Number | GTX110511 |
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| Product Name | TAF II p30 antibody |
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| Full Name | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa |
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| Synonyms | TAF10|TAF2A|TAF2H|TAFII30|TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa |
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| Product Description | Rabbit polyclonal antibody to TAF II p30 (TAF II p30 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa) |
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| Background | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq] |
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| Host | Rabbit |
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| Clonality | Polyclonal |
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| Immunogen | Synthetic peptide contain a sequence corresponding to a region within amino acids 130 and 195 of Human TAF II p30 |
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| Antigen Species | Human |
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| Species Cross Reactivity | Human - Not yet tested in other species |
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| Predicted Cross Reactivity Species | mouse(100%), rat(100%), cow(100%) |
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| Application Note | Antibody reactive against peptide, detects immunogen. Further validation in progress. |
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| Positive Controls | Synthetic peptide: 1:8,000 |
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| Target | TAF II p30 |
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| Predicted Target Size(KDa) | 22 |
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| Cellular Localization | Nucleus |
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| Form Supplied | Liquid |
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| Concentration | 0.46 mg/ml |
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| Purification | Purified by antigen-affinity chromatography. |
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| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
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| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
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| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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