| Catalog Number | GTX101328 |
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| Product Name | BARD1 antibody |
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| Full Name | BRCA1 associated RING domain 1 |
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| Synonyms | BARD1|-|BRCA1 associated RING domain 1 |
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| Product Description | Rabbit polyclonal antibody to BARD1 (BRCA1 associated RING domain 1) |
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| Background | This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. [provided by RefSeq] |
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| Host | Rabbit |
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| Clonality | Polyclonal |
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| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 444 and 710 of Human BARD1 |
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| Antigen Species | Human |
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| Species Cross Reactivity | Human - Not yet tested in other species |
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| Application Note | Antibody reactive against recombinant protein, detects immunogen. Further validation in progress. |
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| Positive Controls | Target recombinant protein |
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| Target | BARD1 |
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| Predicted Target Size(KDa) | 87 |
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| Cellular Localization | Nucleus |
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| Form Supplied | Liquid |
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| Concentration | 4.89 mg/ml |
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| Purification | Affinity purified by Protein A. |
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| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
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| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
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| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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