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	Human　 Detection of human ATM protein using anti-ATM 2C1 monoclonal antibody (GTX70103) by western blot or immunoprecipitation. Detection of ATM (Anti-ATM 2C1, GTX70103) or ATR (Anti-ATR 2B5,GTX70109) by western blot in human Raji whole cell extract.

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ATM [2C1] antibody

	Product Name	Cat No	Package	Price	Special Price	Availability	Qty
	ATM [2C1] antibody	GTX70103	100μg	USD 289.00	-	next day delivery

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Catalog Number	GTX70103
Product Name	ATM [2C1] antibody
Synonyms	472 \| ATM \| 114480 \| Q13315 \| AT1 \| ATA \| ATC \| ATD \| ATDC \| ATE \| DKFZp781A0353 \| MGC74674 \| TEL1 \|
Product Description	Mouse monoclonal [2C1] to ATM
Background	ATM-2C1 recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation.
Host	Mouse
Clonality	Monoclonal
Clone No	2C1
Isotype	IgG1
Immunogen	Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056.
Antigen Species	Human
Species Cross Reactivity	Human, Rat, Mouse, and Monkey - Not yet tested in other species
Tested Applications	ICC/IF, Immunoprecipitation, Western blot. The usefulness of this product in other applications has not been determined.
Application Note	For WB: Use at a dilution of 1:500-1:1,000. Predicted 350 kDa. For IP: Use at a concentration of 1-10 µg/ml. Immunohistochemistry analyses was performed of the cerebral cortex of E14.5 wild-type (+/+) and scid mice - (MC Vemuri, 2001) For immunofluorescence please refer to the publication by Harry Scherthan, et.al., 2000 and Yiyoung Liu, et.al., 2006. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Positive Controls	Raji and lymphoblastoid nuclear lysate
Target	ATM
Predicted Target Size(KDa)	370
Cellular Localization	Nucleus
Form Supplied	Liquid
Concentration	1 mg/ml
Purification	Protein G affinity purified
Storage Buffer	Phosphate-buffered saline, pH 7.4, containing no preservatives
Storage Instruction	Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

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