Human 


ATM [2C1] antibody
Product Name Cat No Package Price Special Price Availability Qty
ATM [2C1] antibody GTX70103 100μg USD 289.00 - next day delivery


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Catalog NumberGTX70103
Product NameATM [2C1] antibody
Synonyms472 | ATM | 114480 | Q13315 | AT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 |
Product DescriptionMouse monoclonal [2C1] to ATM
BackgroundATM-2C1 recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation.
HostMouse
ClonalityMonoclonal
Clone No2C1
IsotypeIgG1
ImmunogenRecombinant protein expressed in E. coli corresponding to amino acids 2577-3056.
Antigen SpeciesHuman
Species Cross ReactivityHuman, Rat, Mouse, and Monkey - Not yet tested in other species
Tested ApplicationsICC/IF, Immunoprecipitation, Western blot. The usefulness of this product in other applications has not been determined.
Application NoteFor WB: Use at a dilution of 1:500-1:1,000. Predicted 350 kDa. For IP: Use at a concentration of 1-10 µg/ml. Immunohistochemistry analyses was performed of the cerebral cortex of E14.5 wild-type (+/+) and scid mice - (MC Vemuri, 2001) For immunofluorescence please refer to the publication by Harry Scherthan, et.al., 2000 and Yiyoung Liu, et.al., 2006. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Positive ControlsRaji and lymphoblastoid nuclear lysate
TargetATM
Predicted Target Size(KDa)370
Cellular LocalizationNucleus
Form SuppliedLiquid
Concentration1 mg/ml
PurificationProtein G affinity purified
Storage BufferPhosphate-buffered saline, pH 7.4, containing no preservatives
Storage InstructionKeep as concentrated solution. Aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
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