| Catalog Number | GTX100229 |
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| Product Name | DAB2 antibody |
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| Full Name | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) |
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| Synonyms | DAB2|DOC-2|DOC2|FLJ26626|disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) |
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| Product Description | Rabbit polyclonal antibody to DAB2 (disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)) |
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| Background | DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta). [provided by RefSeq] |
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| Host | Rabbit |
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| Clonality | Polyclonal |
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| Immunogen | Synthetic peptide contain a sequence corresponding to a region within amino acids 708 and 770 of Human DAB2 |
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| Antigen Species | Human |
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| Species Cross Reactivity | Human - Not yet tested in other species |
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| Tested Applications | IHC (Formalin-fixed paraffin-embedded sections), Western blot. The usefulness of this product in other applications has not been determined. |
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| Application Note | For Dot (tested against immunogen only): Use at an assay dependent dilution. Optimal working dilutions should be determined by the end user. |
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| Positive Controls | 293T | A431 | H1299 | HeLa | HepG2 | Molt-4 | Raji |
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| Target | DAB2 |
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| Predicted Target Size(KDa) | 82 |
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| Cellular Localization | Cytoplasmic vesicle | clathrin-coated vesicle membrane | Membrane | clathrin-coated pit |
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| Form Supplied | Liquid |
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| Concentration | 1 mg/ml |
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| Purification | Purified by antigen-affinity chromatography. |
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| Storage Buffer | 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
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| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
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| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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