|Full Name||Wilms tumor 1|
|Product Description||Rabbit Polyclonal antibody to Wilms Tumor 1 (Wilms tumor 1)|
|Background||This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq]|
|Synonyms||AWT1 antibody, GUD antibody, NPHS4 antibody, WAGR antibody, WIT-2 antibody, WT33 antibody, WT1 antibody, Wilms tumor protein antibody, amino-terminal domain of EWS, last three zinc fingers of the DNA-binding domain of WT1 antibody, Wilms tumor 1 antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Wilms Tumor 1. The exact sequence is proprietary.|
|Species Reactivity||Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Japanese Medaka, Xenopus laevis, Pig, Chicken|
|Predict Reactivity Note||Human (100%), Japanese Medaka (81%), Xenopus laevis (85%), Pig (97%), Chicken (91%)|