|Full Name||xeroderma pigmentosum, complementation group C|
|Product Description||Rabbit Polyclonal antibody to XPC (xeroderma pigmentosum, complementation group C)|
|Background||This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]|
|Synonyms||RAD4 antibody, XP3 antibody, XPCC antibody, XPC antibody, p125 antibody, DNA repair protein complementing XP-C cells antibody, mutant xeroderma pigmentosum group C antibody, "xeroderma pigmentosum, complementation group C antibody"|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human XPC. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (81%), Rat (85%), Bovine (84%)|