|Full Name||zeta-chain (TCR) associated protein kinase 70kDa|
|Product Description||Rabbit Polyclonal antibody to ZAP70 (zeta-chain (TCR) associated protein kinase 70kDa)|
|Background||This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||ZAP-70 Antibody, STCD Antibody, zeta-chain (TCR) associated protein kinase 70kDa Antibody, TZK Antibody, STD Antibody, SRK Antibody|
|Cellular Localization||Cytoplasm (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human ZAP70. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (92%), Bovine (93%)|