| Full Name | zeta chain of T cell receptor associated protein kinase 70kDa |
| Product Description | Mouse monoclonal antibody [SBZAP] to ZAP70 |
| Background | This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Synonyms | ZAP-70 Antibody , STCD Antibody , TZK Antibody , zeta-chain (TCR) associated protein kinase 70kDa Antibody , STD Antibody , SRK Antibody |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | SBZAP |
| Target | ZAP70 |
| Isotype | IgG1 |
| Antigen Species | Human |
| Species Reactivity | Human |
| Conjugation | FITC |