|Full Name||zinc finger, CCHC domain containing 11|
|Product Description||Rabbit Polyclonal antibody to ZCCHC11 (zinc finger, CCHC domain containing 11)|
|Background||Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.|
|Synonyms||DKFZp779C1943 antibody, FLJ42878 antibody, PAPD3 antibody, TUT4 antibody, ZCCHC11 antibody, TUTase 4 antibody, zinc finger CCHC domain-containing protein 11 antibody, terminal uridylyltransferase 4 antibody, PAP associated domain containing 3 antibody, "zinc finger, CCHC domain containing 11 antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human ZCCHC11. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (90%), Rat (89%), Bovine (95%)|