| Full Name | catenin (cadherin-associated protein), alpha 1, 102kDa |
| Background | Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. |
| Synonyms | CAP102 antibody, FLJ36832 antibody, FLJ52416 antibody, CTNNA1 antibody, "cadherin-associated protein,102kDa antibody", alpha-catenin antibody, alphaE-catenin antibody, catenin alpha-1 antibody, renal carcinoma antigen NY-REN-13 antibody, alpha-E-catenin antibody, alpha E-catenin antibody, "catenin (cadherin-associated protein), alpha 1, 102kDa antibody", alpha catenin antibody, alpha catenin |
| Cellular Localization | Cytoplasm , cytoskeleton , Cell junction , adherens junction , Cell membrane |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human alpha 1 Catenin. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse, Rat |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Zebrafish, Xenopus laevis, Rabbit, Rhesus Monkey, Bovine |
| Predict Reactivity Note | Zebrafish (93%), Xenopus laevis (96%), Rabbit (100%), Rhesus Monkey (99%), Bovine (100%) |
| Conjugation | Unconjugated |