|Full Name||actinin, alpha 1|
|Product Description||Rabbit Polyclonal antibody to alpha Actinin 1 (actinin, alpha 1)|
|Background||Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||FLJ40884 antibody, FLJ54432 antibody, ACTN1 antibody, alpha-actinin-1 antibody, F-actin cross-linking protein antibody, actinin 1 smooth muscle antibody, alpha-actinin cytoskeletal isoform antibody, non-muscle alpha-actinin-1 antibody, "actinin, alpha 1 antibody"|
|Cellular Localization||Cytoplasm , cytoskeleton , myofibril , sarcomere , Z-disk |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human alpha Actinin 1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Xenopus laevis, Pig, Chicken, Bovine|
|Predict Reactivity Note||Rat (98%), Zebrafish (98%), Xenopus laevis (97%), Pig (98%), Chicken (97%), Bovine (98%)|