|Full Name||actinin, alpha 2|
|Product Description||Mouse Monoclonal antibody [GT1253] to alpha Actinin 2 (actinin, alpha 2)|
|Background||Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. [provided by RefSeq]|
|Synonyms||CMD1AA Antibody , actinin, alpha 2 Antibody , ACTN2 Antibody|
|Cellular Localization||Cytoplasm , myofibril , sarcomere , Z-disk |
|Target||alpha Actinin 2|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human alpha Actinin 2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Xenopus laevis, Pig, Chicken, Bovine|
|Predict Reactivity Note||Rat (100%), Xenopus laevis (94%), Pig (99%), Chicken (98%), Bovine (99%)|