|Full Name||crystallin, alpha B|
|Product Description||Rabbit polyclonal antibody to crystallin alpha B (crystallin, alpha B)|
|Background||Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. [provided by RefSeq]|
|Synonyms||CRYA2 antibody, CTPP2 antibody, HSPB5 antibody, CRYAB antibody, alpha(B)-crystallin antibody, alpha B crystallin antibody, renal carcinoma antigen NY-REN-27 antibody, heat-shock 20 kD like-protein antibody, alpha-crystallin B chain antibody, alpha crystallin B chain antibody, rosenthal fiber component antibody, heat shock protein beta-5 antibody, "crystallin, alpha B antibody"|
|Target||crystallin alpha B|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human crystallin alpha B. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rabbit, Chicken, Sheep, Rhesus Monkey, Bovine, Guinea pig|
|Predict Reactivity Note||Human (100%), Mouse (97%), Rabbit (97%), Chicken (81%), Sheep (96%), Rhesus Monkey (99%), Bovine (97%), Guinea pig (97%)|