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1 .GTX21904 alpha Synuclein antibody [4B12]

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alpha Synuclein antibody [4B12]


  • Host / ClonalityMouse Monoclonal
  • Clone Name4B12
  • ApplicationsDot, ELISA, IHC, IHC-Fr, IHC-P, WB
  • Species reactivityHuman
  • Publication  ( 5 )
Cat No: GTX21904
Package Price Qty
100 μlUSD 329.00
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  • Anti-alpha Synuclein antibody [4B12] used in Immunohistochemistry (IHC). GTX21904
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    Reference (5)
  • Application Information: alpha Synuclein antibody [4B12]

Catalog Number GTX21904
☆☆☆☆☆
( 0 )
Publication ( 5 )
Product Name alpha Synuclein antibody [4B12]
See all alpha Synuclein products
ApplicationsDot, ELISA, IHC, IHC-Fr, IHC-P, WB
Application NoteDot: Use at a dilution of 1/100 - 1/10000. ELISA: Use at an assay dependent dilution. IHC-P: Use at a dilution of 1/100 - 1/1000. Antigen retrieval is not essential but may optimise staining. IHC-Fr: Use at a dilution of 1/100 - 1/1000. WB: Use at a dilution of 1/100 - 1/10000. Predicted molecular weight: 16 kDa. Optimal dilutions/concentrations should be determined by the end user.
Form SuppliedLiquid
Concentration1 mg/ml (Please refer to the vial label for the specific concentration)
Purification NoteAmmonium sulfate precipitated and dialyzed tissue culture supernatant.

  • Specifications: alpha Synuclein antibody [4B12]

Full Namesynuclein, alpha (non A4 component of amyloid precursor)
BackgroundThe implication of alpha synuclein in neurodegenerative diseases started after the identification of non A beta component of amyloid (NAC peptide) in Alzheimeris disease (AD) brains.There is now a general group of synucleinopathies which implicates alpha synuclein in Lewy body syndromes, Parkinsonis disease, and Alzheimeris disease. Certain missense mutations in the alpha synuclein gene (A53T, A30P) have been linked to the familial Parkinsonis disease (PD). Alpha synuclein is the major component of Lewy bodies and Lewy neuritis in sporadic PD, dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20 kD) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma synuclein and synoretin.The expression is abundant in neurons and typically localized at presynaptic terminals. Antibodies to alpha synuclein provide a specific method to detect Lewy bodies and associated pathological mechanism of PD and AD.
SynonymsSNCA, PD1, NACP, PARK4, 6622, MGC110988, P37840, 127750, PARK1, alpha Synuclein
Cellular LocalizationCytoplasmic and Nuclear. Membrane-bound in dopaminergic neurons.
HostMouse
ClonalityMonoclonal
Clone Name4B12
IsotypeIgG1
ImmunogenRecombinant human alpha synuclein produced in E. coli.
Antigen SpeciesHuman
Species ReactivityHuman
Species Does Not React WithMouse, Rat
ConjugationUnconjugated

  • Storage Conditions: alpha Synuclein antibody [4B12]

Storage BufferPreservative: 0.1% Sodium Azide; Constituents: PBS
Storage InstructionKeep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Cancer > Apoptosis > Anti-apoptosis
  • Cell Biology > Apoptosis > Anti-apoptosis
  • Disease Related > Alzheimer's disease
  • Disease Related > Cardiovascular > Heart > Heart disease
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alpha Synuclein antibody [4B12] validated data
  • Anti-alpha Synuclein antibody [4B12] used in Immunohistochemistry (IHC). GTX21904
    • GTX21904 IHC Image
      IHC analysis of the cortical Lewy body using alpha Synuclein antibody [4B12].
      Top
  • Anti-alpha Synuclein antibody [4B12] used in Immunohistochemistry (IHC). GTX21904
    • GTX21904 IHC Image
      IHC analysis of the cortical Lewy body using alpha Synuclein antibody [4B12].
      Top
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  • Reference for alpha Synuclein antibody [4B12]
Application References Application Reactivity
Refolo V et al. Progressive striatonigral degeneration?in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies. Acta Neuropathol Commun 6 (1):2 (2018). WB Human
Venezia S et al. Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy. Mol Neurodegener 12 (1):52 (2017). WB Human
Pampalakis G et al. KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species. Oncotarget (Epub ahead of print) (2016). WB Human
Helwig M et al. Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice. Brain 139 (Pt 3):856-70 (2016). WB Human
Emmanouilidou E et al. GABA transmission via ATP-dependent K+ channels regulates α-synuclein secretion in mouse striatum. Brain 139 (Pt 3):871-90 (2016). WB
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