alpha Synuclein antibody
|Applications||ICC/IF, IHC-Fr, IHC-P, WB|
Not tested in other applications.
|IHC (Frozen sections)||1:100-1:1000*
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||14 kDa (note)
|Positive Controls||SK-N-AS , mouse brain , rat brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||synuclein, alpha (non A4 component of amyloid precursor)|
|Product Description||Rabbit Polyclonal antibody to alpha Synuclein (synuclein, alpha (non A4 component of amyloid precursor))|
|Background||Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq]|
|Synonyms||MGC110988 antibody, NACP antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, SNCA antibody, non A-beta component of AD amyloid antibody, alpha-synuclein antibody, alpha-synuclein, isoform NACP140 antibody, synuclein alpha-140 antibody, synuclein, alpha (non A4 component of amyloid precursor) antibody|
|Cellular Localization||Cytoplasm , Membrane , Nucleus |
|Immunogen||Full length human alpha Synuclein Recombinant protein.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus laevis, Pig, Chicken, Sheep, Chimpanzee, Bovine|
|Predict Reactivity Note||Xenopus laevis (85%), Pig (97%), Chicken (88%), Sheep (95%), Chimpanzee (100%), Bovine (94%)|