ATM antibody [5C2]
|Full Name||ataxia telangiectasia mutated|
|Synonyms||ATD, 114480, ATA, AT1, ATC, ATE, DKFZp781A0353, 472, ATM, TEL1, ATDC, Q13315, MGC74674|
|Product Description||Mouse monoclonal [5C2] to ATM|
|Background||ATM-5C2 recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation.|
|Immunogen||Recombinant protein expressed in E. coli corresponding to amino acids 980-1512.|
|Species Reactivity||Human, Mouse, Monkey, Rat|
|Applications||ICC/IF, IHC, WB|
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Positive Controls||Raji or Akata whole cell lysate |
|Predicted Target Size||370|
|Purification||Protein G purified|
|Purification Note||From Ascites|
|Storage Buffer||Phosphate-buffered saline, pH7.4, containing no preservatives|
|Storage Instruction||Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid freeze-thaw cycles.|