beta A3 Crystallin antibody [N1C3]
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||25 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , Molt-4 , Raji , mouse fetal eye|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||crystallin, beta A1|
|Product Description||Rabbit Polyclonal antibody to Beta crystallin A3 (crystallin, beta A1)|
|Background||Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'. [provided by RefSeq]|
|Synonyms||CRYB1 antibody, CRYBA1 antibody, beta-crystallin A3 antibody, "crystallin, beta A3 antibody", eye lens structural protein antibody, "crystallin, beta A1 antibody"|
|Immunogen||Full length human beta A3 Crystallin Recombinant protein.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Xenopus Tropicalis, Dog, Rabbit, Chicken, Rhesus Monkey, Bovine, Guinea pig|
|Predict Reactivity Note||Human (100%), Rat (95%), Xenopus Tropicalis (81%), Dog (96%), Rabbit (96%), Chicken (84%), Rhesus Monkey (97%), Bovine (93%), Guinea pig (95%)|