| Full Name | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) |
| Background | This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014] |
| Synonyms | APPI Antibody , APP Antibody , ABETA Antibody , AD1 Antibody , CVAP Antibody , CTFGAMMA Antibody , PN II Antibody , PN2 Antibody , ABPP Antibody , AAA Antibody |
| Cellular Localization | Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). A |
| Specificity | Interacts with the C-termini of both beta Amyloid 1-40 and 1-42. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | BDI910 |
| Isotype | IgG1 |
| Immunogen | C-terminal peptide conjugated to KLH. |
| Antigen Species | Human |
| Species Reactivity | Human |
| Conjugation | Unconjugated |