beta-TrCP antibody [N1C1]
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||69 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||beta-transducin repeat containing|
|Product Description||Rabbit polyclonal antibody to beta-TrCP (beta-transducin repeat containing)|
|Background||This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway. [provided by RefSeq]|
|Synonyms||BETA-TRCP antibody, FBW1A antibody, FBXW1 antibody, FBXW1A antibody, FWD1 antibody, MGC4643 antibody, bTrCP antibody, bTrCP1 antibody, betaTrCP antibody, BTRC antibody, E3RSIkappaB antibody, F-box/WD repeat-containing protein 1A antibody, F-box and WD repeats protein beta-TrCP antibody, F-box and WD-repeat protein 1B antibody, pIkappaBalpha-E3 receptor subunit antibody, beta-TrCP1 antibody, beta-transducin repeat containing antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human beta-TrCP. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Xenopus laevis, Bovine|
|Predict Reactivity Note||Mouse (99%), Xenopus laevis (96%), Bovine (99%)|