|Full Name||c-abl oncogene 1, non-receptor tyrosine kinase|
|Product Description||Rabbit Polyclonal antibody to c-Abl (c-abl oncogene 1, receptor tyrosine kinase)|
|Background|| The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq]|
|Synonyms||ABL antibody, JTK7 antibody, bcr/abl antibody, c-ABL antibody, p150 antibody, v-abl antibody, ABL1 antibody, proto-oncogene tyrosine-protein kinase ABL1 antibody, Abelson tyrosine-protein kinase 1 antibody, proto-oncogene c-Abl antibody, v-abl Abelson murine leukemia viral oncogene homolog 1 antibody, "c-abl oncogene 1, receptor tyrosine kinase antibody", tyrosine-protein kinase ABL1 antibody, bcr/c-abl oncogene protein antibody, "c-abl oncogene 1, non-receptor tyrosine kinase antibody"|
|Cellular Localization||Cytoplasm , cytoskeleton , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human c-Abl. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (83%), Rat (84%), Bovine (86%)|